Mobile Class A β-lactamase Gene

Overview

Journal Microbiol Spectr

Specialty Microbiology

Date 2023 Dec 11

PMID 38078722

Authors

Hirokazu Yano

Masato Suzuki

Lisa Nonaka

Affiliations

Soon will be listed here.

Abstract

Despite increasing reports, class A β-lactamases of environmental bacteria remain very poorly characterized, with limited understanding of their transmission patterns. To address this knowledge gap, we focused on a recently designated GMA family β-lactamase gene, , found in marine bacterial genera such as . This study shows that gammaproteobacterial mobile class A β-lactamase is specialized for penicillin degradation, and is frequently linked to strand-biased circularizing integrative elements (SEs) in sequences in the RefSeq/GenBank database. Evidence for the implication of SEs in β-lactamase environmental transmission provides insights for future surveillance studies of antimicrobial resistance genes in human clinical settings.

Citing Articles

Nationwide genome surveillance of carbapenem-resistant in Japan.

Yano H, Hayashi W, Kawakami S, Aoki S, Anzai E, Zuo H Antimicrob Agents Chemother. 2024; 68(5):e0166923.

PMID: 38564665 PMC: 11064530. DOI: 10.1128/aac.01669-23.

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