Multi-taxon Trends and the Application of Genotoxic Biomarkers in the Analysis of Effluents from Sewage Treatment Plant

Overview

Journal Heliyon

Specialty Social Sciences

Date 2023 Dec 11

PMID 38076150

Authors

Renata Maria Pereira de Freitas

Marcelino Benvindo-Souza

Thiago Bernardi Vieira

Klebber Teodomiro Martins Formiga

Daniela de Melo E Silva

Affiliations

Soon will be listed here.

Abstract

Sewage is a significant source of many contaminants, and the effectiveness of sewage treatment plants (STPs) is fundamental to ensure that the effluents produced by these plants have a minimal impact on aquatic environments and guarantee their long-term sustainability. The present study is based on a global scientometric survey of the published research on the application of genotoxicity biomarkers for the analysis of the effects of the contaminants found in the effluents and residues produced by STPs. The literature search focused on the Web of Science and Scopus databases. Research trends were investigated based on the year of publication of each study, the country in which it was developed, the type(s) of genotoxic assay applied, the model organism(s), the type of study (experimental or field study), the physicochemical parameters analyzed, and the principal findings of the genotoxic assays. A total of 134 papers, published between 1988 and April 2023, were selected for analysis. The studies were conducted in a total of 33 different countries, but primarily in Brazil, China, Germany. These studies employed 16 biomarkers to assess genotoxicity, of which, the micronucleus test was the most used. The studies reported on a number of genotoxic substances, such as pollutants, including pesticides, microplastics, metals, and drugs. The data produced by these studies provide important insights into the genotoxic effect of the xenobiotic agents found in STP effluents, which are capable of damaging the DNA of a range of different organisms.

References

Carita R, Mazzeo D, Marin-Morales M . Comparison of the toxicogenetic potential of sewage sludges from different treatment processes focusing agricultural use. Environ Sci Pollut Res Int. 2019; 26(21):21475-21483. DOI: 10.1007/s11356-019-05453-y. View

Ahkola H, Lindholm-Lehto P, Perkola N, Valitalo P, Merilainen P, Maenpaa K . A preliminary study on the ecotoxic potency of wastewater treatment plant sludge combining passive sampling and bioassays. Sci Total Environ. 2020; 758:143700. DOI: 10.1016/j.scitotenv.2020.143700. View

Brienza M, Mahdi Ahmed M, Escande A, Plantard G, Scrano L, Chiron S . Use of solar advanced oxidation processes for wastewater treatment: Follow-up on degradation products, acute toxicity, genotoxicity and estrogenicity. Chemosphere. 2016; 148:473-80. DOI: 10.1016/j.chemosphere.2016.01.070. View

OBrien J, Grant S, Banks A, Bruno R, Carter S, Choi P . A National Wastewater Monitoring Program for a better understanding of public health: A case study using the Australian Census. Environ Int. 2018; 122:400-411. DOI: 10.1016/j.envint.2018.12.003. View

Oda Y . Advanced Approaches to Model Xenobiotic Metabolism in Bacterial Genotoxicology In Vitro. Adv Biochem Eng Biotechnol. 2016; 157:97-134. DOI: 10.1007/10_2016_4. View

Keiter S, Rastall A, Kosmehl T, Wurm K, Erdinger L, Braunbeck T . Ecotoxicological assessment of sediment, suspended matter and water samples in the upper Danube River. A pilot study in search for the causes for the decline of fish catches. Environ Sci Pollut Res Int. 2006; 13(5):308-19. DOI: 10.1065/espr2006.04.300. View

Crebelli R, Conti L, Monarca S, Feretti D, Zerbini I, Zani C . Genotoxicity of the disinfection by-products resulting from peracetic acid- or hypochlorite-disinfected sewage wastewater. Water Res. 2005; 39(6):1105-13. DOI: 10.1016/j.watres.2004.12.029. View

Campos C, Pereira B, Campos-Junior E, Sousa E, Souto H, Morelli S . Genotoxic evaluation of the River Paranaíba hydrographic basin in Monte Carmelo, MG, Brazil, by the Tradescantia micronucleus. Genet Mol Biol. 2015; 38(4):507-12. PMC: 4763326. DOI: 10.1590/S1415-475738420150117. View

Bolognesi C, Hayashi M . Micronucleus assay in aquatic animals. Mutagenesis. 2010; 26(1):205-13. DOI: 10.1093/mutage/geq073. View

10.

Gohlke J, Portier C . The forest for the trees: a systems approach to human health research. Environ Health Perspect. 2007; 115(9):1261-3. PMC: 1964909. DOI: 10.1289/ehp.10373. View

11.

Bonomo M, Morozesk M, Duarte I, Rocha L, Fernandes M, Matsumoto S . Sewage sludge hazardous assessment: chemical evaluation and cytological effects in CHO-k1 cells. Environ Sci Pollut Res Int. 2016; 23(11):11069-11075. DOI: 10.1007/s11356-016-6201-8. View

12.

Muller R, Tang J, Thier R, Mueller J . Combining passive sampling and toxicity testing for evaluation of mixtures of polar organic chemicals in sewage treatment plant effluent. J Environ Monit. 2007; 9(1):104-9. DOI: 10.1039/b612430e. View

13.

Santos T, Sommaggio L, Marin-Morales M . Phyto-genotoxicity assessment of different associations between sludges from Water and Sewage Treatment Plants, before and after the bioremediation process. Environ Sci Pollut Res Int. 2022; 29(26):40029-40040. DOI: 10.1007/s11356-022-18820-z. View

14.

Klee N, Gustavsson L, Kosmehl T, Engwall M, Erdinger L, Braunbeck T . Changes in toxicity and genotoxicity of industrial sewage sludge samples containing nitro- and amino-aromatic compounds following treatment in bioreactors with different oxygen regimes. Environ Sci Pollut Res Int. 2004; 11(5):313-20. DOI: 10.1007/BF02979645. View

15.

de Souza Celente G, Colares G, da Silva Araujo P, Machado E, Lobo E . Acute ecotoxicity and genotoxicity assessment of two wastewater treatment units. Environ Sci Pollut Res Int. 2020; 27(10):10520-10527. DOI: 10.1007/s11356-019-07308-y. View

16.

Lanier C, Manier N, Cuny D, Deram A . The comet assay in higher terrestrial plant model: Review and evolutionary trends. Environ Pollut. 2015; 207:6-20. DOI: 10.1016/j.envpol.2015.08.020. View

17.

Papa M, Ceretti E, Viviana Viola G, Feretti D, Zerbini I, Mazzoleni G . The assessment of WWTP performance: Towards a jigsaw puzzle evaluation?. Chemosphere. 2015; 145:291-300. DOI: 10.1016/j.chemosphere.2015.11.054. View

18.

Luan H, Zhao J, Yang J, Gao X, Song J, Chen X . Integrated genotoxicity of secondary and tertiary treatment effluents in North China. Sci Total Environ. 2022; 865:161241. DOI: 10.1016/j.scitotenv.2022.161241. View

19.

Ghose A, Mitra S . Spent waste from edible mushrooms offers innovative strategies for the remediation of persistent organic micropollutants: A review. Environ Pollut. 2022; 305:119285. DOI: 10.1016/j.envpol.2022.119285. View

20.

Gatidou G, Arvaniti O, Stasinakis A . Review on the occurrence and fate of microplastics in Sewage Treatment Plants. J Hazard Mater. 2019; 367:504-512. DOI: 10.1016/j.jhazmat.2018.12.081. View