Dissecting Causal Associations of Type 2 Diabetes with 111 Types of Ocular Conditions: a Mendelian Randomization Study

Overview

Journal Front Endocrinol (Lausanne)

Specialty Endocrinology

Date 2023 Dec 11

PMID 38075077

Authors

Rumeng Chen

Shuling Xu

Yining Ding

Leyang Li

Chunxia Huang

MeiHua Bao

Sen Li

Qiuhong Wang

Affiliations

Soon will be listed here.

Abstract

Background: Despite the well-established findings of a higher incidence of retina-related eye diseases in patients with diabetes, there is less investigation into the causal relationship between diabetes and non-retinal eye conditions, such as age-related cataracts and glaucoma.

Methods: We performed Mendelian randomization (MR) analysis to examine the causal relationship between type 2 diabetes mellitus (T2DM) and 111 ocular diseases. We employed a set of 184 single nucleotide polymorphisms (SNPs) that reached genome-wide significance as instrumental variables (IVs). The primary analysis utilized the inverse variance-weighted (IVW) method, with MR-Egger and weighted median (WM) methods serving as supplementary analyses.

Results: The results revealed suggestive positive causal relationships between T2DM and various ocular conditions, including "Senile cataract" (OR= 1.07; 95% CI: 1.03, 1.11; =7.77×10), "Glaucoma" (OR= 1.08; 95% CI: 1.02, 1.13; =4.81×10), and "Disorders of optic nerve and visual pathways" (OR= 1.10; 95% CI: 0.99, 1.23; =7.01×10).

Conclusion: Our evidence supports a causal relationship between T2DM and specific ocular disorders. This provides a basis for further research on the importance of T2DM management and prevention strategies in maintaining ocular health.

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