Optimal Concentration of Ropivacaine for Peripheral Nerve Blocks in Adult Patients: a Protocol for Systematic Review and Meta-analysis

Overview

Journal BMJ Open

Specialty General Medicine

Date 2023 Dec 10

PMID 38072500

Authors

Jing Li

Jiamei Pan

Ying Xu

Yi Wang

Donghang Zhang

Yiyong Wei

Affiliations

Soon will be listed here.

Abstract

Introduction: Ropivacaine is the most widely used local anaesthetic for peripheral nerve blocks (PNBs). The effects of various concentrations of ropivacaine in PNB have been investigated and compared by many randomised controlled trials (RCTs). This protocol aims to identify the optimal concentration of ropivacaine for PNB in adult patients.

Methods And Analysis: PubMed, EMBASE, the Cochrane library and Web of Science will be searched from their inception to 10 July 2023. RCTs that compare the analgesic effects of different concentrations of ropivacaine for PNB will be included. Retrospective studies, meta-analyses, reviews, case reports, letters, conference abstracts and paediatric studies will be excluded. The duration of analgesia will be named as the primary outcome. Secondary outcomes will include the onset time of motor and sensory blockade, postoperative pain scores, analgesic requirements over 24 hours and the incidence of adverse effects. The study selection, data extraction and quality assessment will be performed by two independent reviewers. Data processing and analysis will be performed by RevMan 5.4. The quality of the evidence will be assessed by the Grading of Recommendations Assessment, Development and Evaluation approach.

Ethics And Dissemination: Ethical approval is not applicable. The results of this study will be submitted to peer-reviewed journals.

Prospero Registration Number: CRD42023406362.

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