Intermittent Fasting on Neurologic Diseases: Potential Role of Gut Microbiota

Overview

Journal Nutrients

Date 2023 Dec 9

PMID 38068773

Authors

Mingke Guo

Xuan Wang

Yujuan Li

Ailin Luo

Yilin Zhao

Xiaoxiao Luo

Shiyong Li

Affiliations

Soon will be listed here.

Abstract

As the global population ages, the prevalence of neurodegenerative diseases is surging. These disorders have a multifaceted pathogenesis, entwined with genetic and environmental factors. Emerging research underscores the profound influence of diet on the development and progression of health conditions. Intermittent fasting (IF), a dietary pattern that is increasingly embraced and recommended, has demonstrated potential in improving neurophysiological functions and mitigating pathological injuries with few adverse effects. Although the precise mechanisms of IF's beneficial impact are not yet completely understood, gut microbiota and their metabolites are believed to be pivotal in mediating these effects. This review endeavors to thoroughly examine current studies on the shifts in gut microbiota and metabolite profiles prompted by IF, and their possible consequences for neural health. It also highlights the significance of dietary strategies as a clinical consideration for those with neurological conditions.

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