Adverse Effects of Non-Metallic Nanoparticles in the Central Nervous System

Overview

Journal Materials (Basel)

Publisher MDPI

Date 2023 Dec 9

PMID 38068008

Authors

Katarzyna Sikorska

Krzysztof Sawicki

Magdalena Czajka

Lucyna Kapka-Skrzypczak

Marcin Kruszewski

Kamil Brzoska

Affiliations

Soon will be listed here.

Abstract

The interest in nanoparticles (NPs) and their effects on living organisms has been continuously growing in the last decades. A special interest is focused on the effects of NPs on the central nervous system (CNS), which seems to be the most vulnerable to their adverse effects. Non-metallic NPs seem to be less toxic than metallic ones; thus, the application of non-metallic NPs in medicine and industry is growing very fast. Hence, a closer look at the impact of non-metallic NPs on neural tissue is necessary, especially in the context of the increasing prevalence of neurodegenerative diseases. In this review, we summarize the current knowledge of the in vitro and in vivo neurotoxicity of non-metallic NPs, as well as the mechanisms associated with negative or positive effects of non-metallic NPs on the CNS.

Citing Articles

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