The Role of Apolipoproteins in the Commonest Cancers: A Review

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2023 Dec 9

PMID 38067270

Authors

Nour M Darwish

Mooza Kh Al-Hail

Youssef Mohamed

Rafif Al Saady

Sara Mohsen

Amna Zar

Layla Al-Mansoori

Shona Pedersen

Affiliations

Soon will be listed here.

Abstract

Apolipoproteins (APOs) are vital structural components of plasma lipoproteins that are involved in lipid metabolism and transport. Recent studies have reported an association between apolipoprotein dysregulation and the onset of a variety of human cancers; however, the role of certain APOs in cancer development remains unknown. Based on recent work, we hypothesize that APOs might be involved in the onset of cancer, with a focus on the most common cancers, including breast, lung, gynecological, colorectal, thyroid, gastric, pancreatic, hepatic, and prostate cancers. This review will focus on the evidence supporting this hypothesis, the mechanisms linking APOs to the onset of cancer, and the potential clinical relevance of its various inhibitors.

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