Different Concentrations of Probiotic GT001 on Growth Performance, Antioxidant Capacity, Immune Function, Intestinal Microflora and Histomorphology of Broiler Chickens

Overview

Journal Animals (Basel)

Date 2023 Dec 9

PMID 38067075

Authors

Gifty Ziema Bumbie

Leonardo Abormegah

Peter Asiedu

Akua Durowaa Oduro-Owusu

Frederick Danso

Kwabena Owusu Ansah

Taha Mohamed Mohamed

Zhiru Tang

Affiliations

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Abstract

Exploring alternatives to antibiotics is imperative in reducing antibiotic resistance and antibiotic residues in poultry products. The beneficial effects of antibiotic products derived from natural sources in comparison with the synthetic ones has been reported. has been applied as an animal growth bio-promoter and probiotic. To elucidate the protective mechanisms of , this study investigated the effects of different doses of supplementation on broiler growth performance, immune function, intestinal development and histomorphology. Five hundred (500) one-day-old Ross 708 broiler chicks were randomly enrolled into five experimental groups with 20 chicks per replicate. The treatments were imposed as follows: (T1) basal diet (control); (T2) basal diet with 1 g/kg antibact 3X; (T3) basal diet with GT001 at 4.0 × 10 cfu/g; (T4) basal diet with GT001 at 8.0 × 10 cfu/g; and (T5) basal diet with GT001 at 1.2 × 10 cfu/g. Dietary inclusion of GT001 at 4.0 × 10 cfu/g significantly improved body weight gain, feed intake and lipid profile of the broilers compared to the control group ( 0.05). The addition of GT001 significantly improved the intestinal pH of the broilers. The digestive enzymes of the broilers were impacted with the supplementation of GT001 at 4.0 × 10 cfu/g. The highest serum antioxidant production was observed in the -treated group compared to the control. GT001 at 4.0 × 10 cfu/g increased the levels of serum cytokines and immunoglobin and improved the small intestinal morphology of the broilers in comparison with the control. The load of was similar among T3, T4 and T5 but significantly higher than that of the control (T1) and the antibiotics (T2)-fed birds. The load of in the gut was significantly reduced in T3, T4 and T5 compared to T1 and T2. There was no growth among the treatments. This study highlights the importance of probiotics in broiler diets and suggests that GT001 could be used as a feasible substitute to antimicrobials in broiler production.

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