Hybrid AuNPs-3MPS-MTX Nanosystem and Its Evaluation for Treating Cervical Cancer and Melanoma

Overview

Journal Nanoscale Adv

Publisher Royal Society of Chemistry

Specialty Biotechnology

Date 2023 Dec 7

PMID 38059041

Authors

M J Hernandez-Esparza

Ilaria Fratoddi

Sara Cerra

K Juarez-Moreno

R Huirache-Acuna

Affiliations

Soon will be listed here.

Abstract

This research presents an evaluation of a hybrid material based on gold nanoparticles (AuNPs), stabilized with the thiol 3-mercapto-propanesulfonate (3MPS) and loaded with the methotrexate drug (MTX). The AuNPs-3MPS-MTX nanosystem was tested for the treatment of cervical cancer and melanoma, using the B16-F10 melanoma and HeLa cell lines. The tests performed on cell cultures assessed the efficiency of the studied nanosystem on tumor cells, as well as its toxicology.

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