Phantom-Based Standardization Method for I-metaiodobenzylguanidine Heart-to-Mediastinum Ratio Validated by D-SPECT Versus Anger Camera

Overview

Journal Ann Nucl Cardiol

Date 2023 Dec 7

PMID 38058581

Authors

Shozo Yamashita

Kenichi Nakajima

Koichi Okuda

Haruki Yamamoto

Takayuki Shibutani

Tatsuya Yoneyama

Shiro Tsuji

Kunihiko Yokoyama

Affiliations

Soon will be listed here.

Abstract

: The I-metaiodobenzylguanidine heart-to-mediastinum ratios (HMRs) have been standardized between D-SPECT and Anger cameras in a small patient cohort using a phantom-based conversion method. This study aimed to determine the validity of this method and compare the diagnostic performance of the two cameras in a larger patient cohort. : We retrospectively calculated HMRs from early and late anterior-planar equivalent and planar images acquired from 173 patients in 177 studies using D-SPECT and Anger cameras, respectively. The D-SPECT HMRs were cross-calibrated to an Anger camera using conversion coefficients based on previous phantom findings, then standardized to medium-energy general-purpose collimator conditions. Relationships between HMRs before and after corrections were investigated. Late HMRs were classified into four cardiac mortality risk groups and divided into two groups using a threshold of 2.2 to verify diagnostic performance concordance. : Correction improved linear regression lines and differences in HMRs among the groups. The overall ratios of perfect concordance were (134 [75.7%] of 177), and higher in groups with very low (49 [80.3%] of 61) and high (51 [86.4%] of 59) HMRs when the standardized HMR was classified according to cardiac mortality risk. That between the systems was the highest (164 [92.7%] of 177) when the HMR was divided by a threshold value of 2.2. : Phantom-based conversion can standardize HMRs between D-SPECT and Anger cameras because the standardized HMR provided comparable diagnostic performance. Our findings indicated that this conversion could be applied to multicenter studies that include both D-SPECT and Anger cameras.

Citing Articles

Comparison of Taiwanese and European Calibration Factors for Heart-to-Mediastinum Ratio in Multicenter I-mIBG Phantom Studies.

Okuda K, Nakajima K, Hung G, Wu H, Verschure D, Verberne H Ann Nucl Cardiol. 2023; 9(1):54-60.

PMID: 38058572 PMC: 10696153. DOI: 10.17996/anc.23-00006.

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