Gnathic Schwannomas: A Report of Two Cases and Systematic Review of the Literature

Overview

Journal Head Neck Pathol

Specialties Oncology
Pathology

Date 2023 Dec 6

PMID 38055108

Authors

Alberto Jose Peraza Labrador

Luciano Hermios Matos Valdez

Nestor Ricardo Gonzalez Marin

Karem Annelise Rodriguez Ibazetta

Marcelo Villacis

Joan Lopez Chacon

Hebert Ochoa Huaman

Harold Cuzcano Pariahuaman

Hosting Barria Angulo

Victoria Woo

Affiliations

Soon will be listed here.

Abstract

Background: The intraosseous schwannoma (IS) is a benign peripheral nerve sheath tumor postulated to arise de novo or from nerve fibers in preexisting nutrient canals. ISs are uncommon and comprise less than 1% of neoplasms originating in bone. We herein present two cases of mandibular schwannomas-the first case was a 66-year-old female with a four-month history of pain and pressure associated with an anterior mandibular radiolucency, and the second case was an asymptomatic 12-year-old female with separate radiolucencies of her mandibular symphysis and right posterior mandible. Incisional biopsies of all three lesions showed a benign spindle cell neoplasm with histologic features of a schwannoma; the tumor cells were strongly reactive for S-100. The patients underwent complete enucleation of their lesions and are without evidence of disease at ten months and five years, respectively.

Methods: A systematic review was undertaken to evaluate the diagnostic features, treatment, and patient outcomes of gnathic schwannomas.

Results: A total of 93 cases were identified with the following demographic findings: predominance in females (57%); average age of occurrence of 37.3 years (8 to 77 years); mean size of 3.6 cm; and involvement of the mandibular body (37.6%), mandibular body and ramus (18.3%), and anterior mandible (18.3%). The predominant clinical sign was swelling (69.9%), and the most common radiographic presentation was a radiolucency (94.6%) with well-defined borders (72%).

Conclusion: All cases were treated surgically, with an average follow-up interval of 22.9 months and a recurrence rate of 5.4.

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