Enhancing Visual Perceptual Learning Using Transcranial Electrical Stimulation: Transcranial Alternating Current Stimulation Outperforms Both Transcranial Direct Current and Random Noise Stimulation

Overview

Journal J Vis

Specialty Ophthalmology

Date 2023 Dec 6

PMID 38054934

Authors

Qing He

Xinyi Zhu

Fang Fang

Affiliations

Soon will be listed here.

Abstract

Diverse strategies can be employed to enhance visual skills, including visual perceptual learning (VPL) and transcranial electrical stimulation (tES). Combining VPL and tES is a popular method that holds promise for producing significant improvements in visual acuity within a short time frame. However, there is still a lack of comprehensive evaluation regarding the effects of combining different types of tES and VPL on enhancing visual function, especially with a larger sample size. In the present study, we recruited four groups of subjects (26 subjects each) to learn an orientation discrimination task with five daily training sessions. During training, the occipital region of each subject was stimulated by one type of tES-anodal transcranial direct current stimulation (tDCS), alternating current stimulation (tACS) at 10 Hz, high-frequency random noise stimulation (tRNS), and sham tACS-while the subject performed the training task. We found that, compared with the sham stimulation, both the high-frequency tRNS and the 10-Hz tACS facilitated VPL efficiently in terms of learning rate and performance improvement, but there was little modulatory effect in the anodal tDCS condition. Remarkably, the 10-Hz tACS condition exhibited superior modulatory effects compared with the tRNS condition, demonstrating the strongest modulation among the most commonly used tES types for further enhancing vision when combined with VPL. Our results suggest that alpha oscillations play a vital role in VPL. Our study provides a practical guide for vision rehabilitation.

References

He Q, Lin B, Zhao J, Shi Y, Yan F, Huang C . No effects of anodal transcranial direct current stimulation on contrast sensitivity function. Restor Neurol Neurosci. 2019; 37(2):109-118. DOI: 10.3233/RNN-180881. View

Wu D, Zhang P, Wang Y, Liu N, Sun K, Wang P . Anodal online transcranial direct current stimulation facilitates visual motion perceptual learning. Eur J Neurosci. 2022; 57(3):479-489. DOI: 10.1111/ejn.15895. View

Clayton M, Yeung N, Cohen Kadosh R . Electrical stimulation of alpha oscillations stabilizes performance on visual attention tasks. J Exp Psychol Gen. 2018; 148(2):203-220. DOI: 10.1037/xge0000502. View

Pirulli C, Fertonani A, Miniussi C . Is neural hyperpolarization by cathodal stimulation always detrimental at the behavioral level?. Front Behav Neurosci. 2014; 8:226. PMC: 4073198. DOI: 10.3389/fnbeh.2014.00226. View

He Q, Yang X, Zhao D, Fang F . Enhancement of visual perception by combining transcranial electrical stimulation and visual perceptual training. Med Rev (2021). 2023; 2(3):271-284. PMC: 10388778. DOI: 10.1515/mr-2022-0010. View

Michael E, Covarrubias L, Leong V, Kourtzi Z . Learning at your brain's rhythm: individualized entrainment boosts learning for perceptual decisions. Cereb Cortex. 2022; 33(9):5382-5394. PMC: 10152088. DOI: 10.1093/cercor/bhac426. View

Contemori G, Trotter Y, Cottereau B, Maniglia M . tRNS boosts perceptual learning in peripheral vision. Neuropsychologia. 2019; 125:129-136. DOI: 10.1016/j.neuropsychologia.2019.02.001. View

Johnson L, Alekseichuk I, Krieg J, Doyle A, Yu Y, Vitek J . Dose-dependent effects of transcranial alternating current stimulation on spike timing in awake nonhuman primates. Sci Adv. 2020; 6(36). PMC: 7467690. DOI: 10.1126/sciadv.aaz2747. View

Learmonth G, Thut G, Benwell C, Harvey M . The implications of state-dependent tDCS effects in aging: Behavioural response is determined by baseline performance. Neuropsychologia. 2015; 74:108-19. DOI: 10.1016/j.neuropsychologia.2015.01.037. View

10.

Frangou P, Correia M, Kourtzi Z . GABA, not BOLD, reveals dissociable learning-dependent plasticity mechanisms in the human brain. Elife. 2018; 7. PMC: 6202049. DOI: 10.7554/eLife.35854. View

11.

Zizlsperger L, Kummel F, Haarmeier T . Metacognitive Confidence Increases with, but Does Not Determine, Visual Perceptual Learning. PLoS One. 2016; 11(3):e0151218. PMC: 4794197. DOI: 10.1371/journal.pone.0151218. View

12.

Van Meel C, Daniels N, Op de Beeck H, Baeck A . Effect of tDCS on task relevant and irrelevant perceptual learning of complex objects. J Vis. 2016; 16(6):13. DOI: 10.1167/16.6.13. View

13.

Reinhart R, Xiao W, McClenahan L, Woodman G . Electrical Stimulation of Visual Cortex Can Immediately Improve Spatial Vision. Curr Biol. 2016; 26(14):1867-72. PMC: 4961578. DOI: 10.1016/j.cub.2016.05.019. View

14.

Huang W, Stitt I, Negahbani E, Passey D, Ahn S, Davey M . Transcranial alternating current stimulation entrains alpha oscillations by preferential phase synchronization of fast-spiking cortical neurons to stimulation waveform. Nat Commun. 2021; 12(1):3151. PMC: 8149416. DOI: 10.1038/s41467-021-23021-2. View

15.

Lu Z, Lin Z, Dosher B . Translating Perceptual Learning from the Laboratory to Applications. Trends Cogn Sci. 2016; 20(8):561-563. PMC: 5568120. DOI: 10.1016/j.tics.2016.05.007. View

16.

Hadlow S, Panchuk D, Mann D, Portus M, Abernethy B . Modified perceptual training in sport: A new classification framework. J Sci Med Sport. 2018; 21(9):950-958. DOI: 10.1016/j.jsams.2018.01.011. View

17.

Ghin F, Pavan A, Contillo A, Mather G . The effects of high-frequency transcranial random noise stimulation (hf-tRNS) on global motion processing: An equivalent noise approach. Brain Stimul. 2018; 11(6):1263-1275. DOI: 10.1016/j.brs.2018.07.048. View

18.

Camilleri R, Pavan A, Ghin F, Battaglini L, Campana G . Improvement of uncorrected visual acuity and contrast sensitivity with perceptual learning and transcranial random noise stimulation in individuals with mild myopia. Front Psychol. 2014; 5:1234. PMC: 4212604. DOI: 10.3389/fpsyg.2014.01234. View

19.

Grasso P, Tonolli E, Miniussi C . Effects of different transcranial direct current stimulation protocols on visuo-spatial contextual learning formation: evidence of homeostatic regulatory mechanisms. Sci Rep. 2020; 10(1):4622. PMC: 7067887. DOI: 10.1038/s41598-020-61626-7. View

20.

Frank S, Qi A, Ravasio D, Sasaki Y, Rosen E, Watanabe T . Supervised Learning Occurs in Visual Perceptual Learning of Complex Natural Images. Curr Biol. 2020; 30(15):2995-3000.e3. PMC: 7415644. DOI: 10.1016/j.cub.2020.05.050. View