Development of a Fumonisin-sensitive Indicator Strain and Utilization for Activity Testing of Candidate Detoxification Genes

Overview

Journal Appl Environ Microbiol

Specialties Environmental Health
Microbiology

Date 2023 Dec 6

PMID 38054733

Authors

Tamara Krska

Krisztian Twaruschek

Nina Valente

Rudolf Mitterbauer

Dieter Moll

Gerlinde Wiesenberger

Franz Berthiller

Gerhard Adam

Affiliations

Soon will be listed here.

Abstract

Fumonisins can cause diseases in animals and humans consuming -contaminated food or feed. The search for microbes capable of fumonisin degradation, or for enzymes that can detoxify fumonisins, currently relies primarily on chemical detection methods. Our constructed fumonisin B1-sensitive yeast strain can be used to phenotypically detect detoxification activity and should be useful in screening for novel fumonisin resistance genes and to elucidate fumonisin metabolism and resistance mechanisms in fungi and plants, and thereby, in the long term, help to mitigate the threat of fumonisins in feed and food.

Citing Articles

Mechanism of Fumonisin Self-Resistance: Contains Four Fumonisin B-Insensitive-Ceramide Synthases.

Krska T, Twaruschek K, Wiesenberger G, Berthiller F, Adam G Toxins (Basel). 2024; 16(6).

PMID: 38922130 PMC: 11209526. DOI: 10.3390/toxins16060235.

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