The Dynamic Nexus: Exploring the Interplay of BMI Before, During, and After Pregnancy with Metabolic Syndrome (MetS) Risk in Chinese Lactating Women

Overview

Journal BMC Public Health

Publisher Biomed Central

Specialty Public Health

Date 2023 Dec 5

PMID 38053120

Authors

Liangxia Chen

Jie Ma

Guanmin Su

Longlong Yin

Xiuyu Jiang

Xiangxiang Wang

Lele Liu

Xiaofei Zhang

Xiaohui Xu

Suyun Li

Gaohui Zhang

Ran Zhao

Lianlong Yu

Affiliations

Soon will be listed here.

Abstract

Background And Aim: The health implications of BMI and MetS in lactating women are significant. This study aims to investigate the relationship between risk of Mets in lactation and BMI in four stages: pre-pregnancy, prenatal period, 42 days postpartum, and current lactation.

Methods And Results: A total of 1870 Lactating Women within 2 years after delivery were included from "China Child and Lactating Mother Nutrition Health Surveillance (2016-2017)". Logistic regression model and Restricted cubic spline (RCS) were used to estimate the relationship between BMI and risk of MetS. ROC analysis was used to determine the threshold for the risk of MetS. Chain mediating effect analysis was used to verify the mediating effect. BMI of MetS group in all stages were higher than non-MetS group (P < 0.0001). There were significant positive correlations between BMI in each stage and ORs of MetS during lactation (P < 0.05). The best cut-off values for BMI in the four stages were 23.47, 30.49, 26.04 and 25.47 kg/m. The non-linear spline test at BMI in 42 days postpartum, current and MetS in lactation was statistically significant (P non-linear = 0.0223, 0.0003). The mediation effect of all chains have to work through lactation BMI. The total indirect effect accounted for 80.95% of the total effect.

Conclusions: The risk of MetS in lactating women is due to a high BMI base before pregnancy and postpartum. High BMI in all stages of pregnancy and postpartum were risk factors for MetS in lactation. BMI during lactation plays a key role in the risk of MetS.

Citing Articles

Characteristics of Glucose-Lipid Metabolism in Early Pregnancy Among Overweight and Obese Women and Their Predictive Value for Gestational Diabetes Mellitus.

Chen X, Zhang J, Tang Y, Zhang Y, Ma Z, Hu Y Diabetes Metab Syndr Obes. 2024; 17:3711-3723.

PMID: 39539456 PMC: 11558444. DOI: 10.2147/DMSO.S469957.

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