Risk of Metabolic Abnormalities in Osteoarthritis: a New Perspective to Understand Its Pathological Mechanisms

Overview

Journal Bone Res

Specialties Endocrinology
Orthopedics

Date 2023 Dec 5

PMID 38052778

Authors

Guizheng Wei

Ke Lu

Muhammad Umar

Zhenglin Zhu

William W Lu

John R Speakman

Yan Chen

Liping Tong

Di Chen

Affiliations

Soon will be listed here.

Abstract

Although aging has traditionally been viewed as the most important risk factor for osteoarthritis (OA), an increasing amount of epidemiological evidence has highlighted the association between metabolic abnormalities and OA, particularly in younger individuals. Metabolic abnormalities, such as obesity and type II diabetes, are strongly linked to OA, and they affect both weight-bearing and non-weight-bearing joints, thus suggesting that the pathogenesis of OA is more complicated than the mechanical stress induced by overweight. This review aims to explore the recent advances in research on the relationship between metabolic abnormalities and OA risk, including the impact of abnormal glucose and lipid metabolism, the potential pathogenesis and targeted therapeutic strategies.

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