EEG Power Spectral Density in NREM Sleep is Associated with the Degree of Hypoxia in Patients with Obstructive Sleep Apnea

Overview

Journal Nat Sci Sleep

Publisher Dove Medical Press

Date 2023 Dec 4

PMID 38046177

Authors

Chan Zhang

Yanhui Wang

Dongxiao Li

Mengjie Li

Xiaofeng Zhang

Wenzheng Rong

Pu Wang

Lanjun Li

Shujing He

Yuming Xu

Yusheng Li

Affiliations

Soon will be listed here.

Abstract

Purpose: Obstructive sleep apnea (OSA) is a prevalent sleep-related breathing disorder. Research conducted on patients with OSA using electroencephalography (EEG) has revealed a noticeable shift in the overnight polysomnography (PSG) power spectrum. To better quantify the effects of OSA on brain function and to identify the most reliable predictors of pathological cortical activation, this study quantified the PSG power and its association with the degree of hypoxia in OSA patients.

Patients And Methods: This retrospective study recruited 93 patients with OSA. OSA patients were divided into three groups based on their apnea-hypopnea index (AHI) scores. The clinical characteristics and sleep macrostructure of these patients were examined, followed by an analysis of PSG signals. Power spectral density (PSD) in five frequency bands was analyzed during nonrapid eye movement (NREM) sleep, rapid eye movement (REM) sleep, and wakefulness. Finally, correlation analysis was conducted to assess the relationships among PSD, PSG parameters, and serum levels of S100β and uric acid.

Results: Obstructive sleep apnea occurred during both the NREM and REM sleep phases. Except for a decrease in the duration of N2 sleep and an increase in the microarousal index, there were no significant differences in sleep architecture based on disease severity. Compared to the mild OSA group, the theta and alpha band PSD in the frontal and occipital regions during NREM sleep and wakefulness were significantly decreased in the moderate and severe OSA groups. Correlation analysis revealed that theta PSD in N1 and N3 stages were negatively correlated the AHI, oxygen desaturation index, SaO2<90% and microarousal index.

Conclusion: These findings imply that patients with more severe OSA exhibited considerable NREM hypoxia and abnormal brain activity in the frontal and occipital regions. Therefore, sleep EEG oscillation may be a useful neurophysiological indicator for assessing brain function and disease severity in patients with OSA.

Citing Articles

Changes in the Spatial Structure of Synchronization Connections in EEG During Nocturnal Sleep Apnea.

Zhuravlev M, Kiselev A, Orlova A, Egorov E, Drapkina O, Simonyan M Clocks Sleep. 2025; 7(1.

PMID: 39846529 PMC: 11755653. DOI: 10.3390/clockssleep7010001.

Phase-Amplitude Coupling in Theta and Beta Bands: A Potential Electrophysiological Marker for Obstructive Sleep Apnea.

Zhang C, Wang Y, Li M, Niu P, Li S, Hu Z Nat Sci Sleep. 2024; 16:1469-1482.

PMID: 39323903 PMC: 11423842. DOI: 10.2147/NSS.S470617.

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