Two Complementation Groups of Fanconi's Anemia Differ in Their Phenotypic Response to a DNA-crosslinking Treatment

Overview

Journal Hum Genet

Specialty Genetics

Date 1987 Jan 1

PMID 3804331

Citations 11

Authors

E MOUSTACCHI

D Papadopoulo

C Diatloff-Zito

M Buchwald

Affiliations

Soon will be listed here.

Abstract

The two genetic complementation groups reported for Fanconi's anemia (FA) correspond to two phenotypic classes as characterized by measurements of the rate of DNA semiconservative synthesis after 8-methoxypsoralen photoaddition. This test allows a rapid genetic classification of FA patients which appears to be a prerequisite for investigations of the biochemical defect(s) in FA.

Citing Articles

Subtyping analysis of Fanconi anemia by immunoblotting and retroviral gene transfer.

Pulsipher M, Kupfer G, Naf D, Suliman A, Lee J, Jakobs P Mol Med. 1998; 4(7):468-79.

PMID: 9713825 PMC: 2230330.

A damage-recognition protein which binds to DNA containing interstrand cross-links is absent or defective in Fanconi anemia, complementation group A, cells.

Hang B, Yeung A, Lambert M Nucleic Acids Res. 1993; 21(18):4187-92.

PMID: 8414972 PMC: 310048. DOI: 10.1093/nar/21.18.4187.

Localization of Fanconi anemia C protein to the cytoplasm of mammalian cells.

Youssoufian H Proc Natl Acad Sci U S A. 1994; 91(17):7975-9.

PMID: 8058745 PMC: 44527. DOI: 10.1073/pnas.91.17.7975.

Irreversible repression of DNA synthesis in Fanconi anemia cells is alleviated by the product of a novel cyclin-related gene.

Digweed M, Gunthert U, Schneider R, Seyschab H, Friedl R, Sperling K Mol Cell Biol. 1995; 15(1):305-14.

PMID: 7799938 PMC: 231958. DOI: 10.1128/MCB.15.1.305.

Microinjection of normal cell extracts into Fanconi anemia fibroblasts corrects defective scheduled DNA synthesis recovery after 8-methoxypsoralen plus UVa treatment.

Gok M, Wunder E Hum Genet. 1987; 75(4):350-5.

PMID: 3570290 DOI: 10.1007/BF00284106.

References

Sasaki M, Tonomura A . A high susceptibility of Fanconi's anemia to chromosome breakage by DNA cross-linking agents. Cancer Res. 1973; 33(8):1829-36. View

Fujiwara Y . Defective repair of mitomycin C crosslinks in Fanconi's anemia and loss in confluent normal human and xeroderma pigmentosum cells. Biochim Biophys Acta. 1982; 699(3):217-25. DOI: 10.1016/0167-4781(82)90110-5. View

Auerbach A, WOLMAN S . Susceptibility of Fanconi's anaemia fibroblasts to chromosome damage by carcinogens. Nature. 1976; 261(5560):494-6. DOI: 10.1038/261494a0. View

Fornace Jr A, Little J, Weichselbaum R . DNA repair in a Fanconi's anemia fibroblast cell strain. Biochim Biophys Acta. 1979; 561(1):99-109. DOI: 10.1016/0005-2787(79)90494-5. View

Gruenert D, Cleaver J . Repair of psoralen-induced cross-links and monoadducts in normal and repair-deficient human fibroblasts. Cancer Res. 1985; 45(11 Pt 1):5399-404. View

Cleaver J, Gruenert D . Repair of psoralen adducts in human DNA: differences among xeroderma pigmentosum complementation groups. J Invest Dermatol. 1984; 82(4):311-5. DOI: 10.1111/1523-1747.ep12260596. View

Dutrillaux B, Aurias A, Dutrillaux A, Buriot D, PRIEUR M . The cell cycle of lymphocytes in Fanconi anemia. Hum Genet. 1982; 62(4):327-32. DOI: 10.1007/BF00304549. View

Claassen E, Kortbeek H, Arwert F . Effects of mitomycin C on the rate of DNA synthesis in normal and Fanconi anaemia cells. Mutat Res. 1986; 165(1):15-9. DOI: 10.1016/0167-8817(86)90004-0. View

Fujiwara Y, Tatsumi M . Cross-link repair in human cells and its possible defect in Fanconi's anemia cells. J Mol Biol. 1977; 113(4):635-49. DOI: 10.1016/0022-2836(77)90227-3. View

10.

Kaye J, Smith C, HANAWALT P . DNA repair in human cells containing photoadducts of 8-methoxypsoralen or angelicin. Cancer Res. 1980; 40(3):696-702. View

11.

Lehmann A, Mayne L . Abnormal kinetics of DNA synthesis in ultraviolet light-irradiated cells from patients with Cockayne's syndrome. Cancer Res. 1979; 39(10):4237-41. View

12.

FANCONI G . Familial constitutional panmyelocytopathy, Fanconi's anemia (F.A.). I. Clinical aspects. Semin Hematol. 1967; 4(3):233-40. View

13.

Elmore E, Swift M . Growth of cultured cells from patients with Fanconi anemia. J Cell Physiol. 1975; 87(2):229-33. DOI: 10.1002/jcp.1040870211. View

14.

Ishida R, Buchwald M . Susceptibility of Fanconi's anemia lymphoblasts to DNA-cross-linking and alkylating agents. Cancer Res. 1982; 42(10):4000-6. View

15.

SCHROEDER T, Tilgen D, Kruger J, Vogel F . Formal genetics of Fanconi's anemia. Hum Genet. 1976; 32(3):257-88. DOI: 10.1007/BF00295817. View

16.

Rude J, Friedberg E . Semi-conservative deoxyribonucleic acid synthesis in unirradiated and ultraviolet-irradiated xeroderma pigmentosum and normal human skin fibroblasts. Mutat Res. 1977; 42(3):433-42. DOI: 10.1016/s0027-5107(77)80047-x. View

17.

Glanz A, Fraser F . Spectrum of anomalies in Fanconi anaemia. J Med Genet. 1982; 19(6):412-6. PMC: 1048952. DOI: 10.1136/jmg.19.6.412. View

18.

MOUSTACCHI E, Diatloff-Zito C . DNA semi-conservative synthesis in normal and Fanconi anemia fibroblasts following treatment with 8-methoxypsoralen and near ultraviolet light or with X-rays. Hum Genet. 1985; 70(3):236-42. DOI: 10.1007/BF00273448. View

19.

Hulten M, Mann J, Taylor A . Clinical and cytogenetic diversity in Fanconi's anaemia. J Med Genet. 1984; 21(3):197-203. PMC: 1049266. DOI: 10.1136/jmg.21.3.197. View

20.

SCHROEDER T, ANSCHUTZ F, Knopp A . [Spontaneous chromosome aberrations in familial panmyelopathy]. Humangenetik. 1964; 1(2):194-6. DOI: 10.1007/BF00389636. View