Systematic Proteomics Profiling of Lysine Crotonylation of the Lung at Pseudoglandular and Canalicular Phases in Human Fetus

Overview

Journal Proteome Sci

Publisher Biomed Central

Date 2023 Dec 1

PMID 38041078

Authors

Wei Wang

Wei Shi

Yinglan Wang

Yane Yang

Ping Li

Zhipeng Zeng

Wenlong Hu

Yumei Chen

Donge Tang

Yong Dai

Affiliations

Soon will be listed here.

Abstract

Lung tissue is an important organ of the fetus, and genomic research on its development has improved our understanding of the biology of this tissue. However, the proteomic research of developing fetal lung tissue is still very scarce. We conducted comprehensive analysis of two developmental stages of fetal lung tissue of proteomics. It showed the developmental characteristics of lung tissue, such as the down-regulation of metabolism-related protein expression, the up-regulation of cell cycle-related proteins, and the regulation in proteins and pathways related to lung development. In addition, we also discovered some key core proteins related to lung development, and provided some key crotonylation modification sites that regulation during lung tissue development. Our comprehensive analysis of lung proteomics can provide a more comprehensive understanding of the developmental status of lung tissue, and provide a certain reference for future research and epigenetics of lung tissue.

Citing Articles

Identification of proteome-wide and functional analysis of lysine crotonylation in multiple organs of the human fetus.

Huang L, Chen H, Yan Q, Zeng Z, Wang Y, Guo H Proteome Sci. 2025; 23(1):2.

PMID: 40082858 PMC: 11905482. DOI: 10.1186/s12953-025-00240-9.

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