Amide N-C Bond Activation: A Graphical Overview of Acyl and Decarbonylative Coupling

Overview

Journal SynOpen

Date 2023 Dec 1

PMID 38037650

Authors

Chengwei Liu

Michal Szostak

Affiliations

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Abstract

This Graphical Review provides an overview of amide bond activation achieved by selective oxidative addition of the N-C(O) acyl bond to transition metals and nucleophilic acyl addition, resulting in acyl and decarbonylative coupling together with key mechanistic details pertaining to amide bond distortion underlying this reactivity manifold.

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PMID: 39115156 PMC: 11614710. DOI: 10.1039/d4dt01829j.

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