Tumour Necrosis Factor is a Compact Trimer

Overview

Journal FEBS Lett

Specialty Biochemistry

Date 1987 Jan 26

PMID 3803597

Citations 28

Authors

P Wingfield

R H Pain

S Craig

Affiliations

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Abstract

Recombinant produced human tumour necrosis factor (TNF) has been studied to characterise the subunit structure of the protein. TNF is shown to be a trimer Mr 52000 in which the subunits are associated in a compact, triangular form. In secondary structure it belongs to the all-beta class of proteins. It has high thermodynamic stability and the unfolded subunits can fold and associate spontaneously to form native, biologically active TNF.

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