Possible Role of 5-Hydroxytryptamine (5-HT) Receptor on Human Sperm Motility Regulation

Overview

Journal Cureus

Specialty Biomedical Engineering

Date 2023 Nov 30

PMID 38033435

Authors

Maya Omote

Yu Wakimoto

Hiroaki Shibahara

Affiliations

Soon will be listed here.

Abstract

The purpose of this study is to examine whether 5-hydroxytryptamine (5-HT, also known as serotonin) regulates human sperm motility, focusing on 5-HT receptors. Immunofluorescent staining revealed the existence of seven types of 5-HT receptors with a heterogeneous pattern of reactive sites. In detail, 5-HT, 5-HT, and 5-HT were detected in the post-acrosomal and mid-piece regions. The 5-HT and 5-HT receptors were mainly localized in the equatorial segment. 5-HT and 5-HT receptors were present in the neck and post-acrosomal regions. When examining the effects of 5-HT receptor antagonists on sperm motility, only the 5-HT receptor antagonist significantly reduced sperm motility. This suggests that the 5-HT receptor may have a regulatory function in sperm motility. Eventually, progressive motility should be attenuated to penetrate the oocyte for fertilization. The current study indicated heterogenous expression patterns and plausible functions of 5-HT receptors in human sperm.

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