» Articles » PMID: 38033424

A Conserved Role for in Sleep Architecture

Overview
Journal Sleep Adv
Date 2023 Nov 30
PMID 38033424
Authors
Affiliations
Soon will be listed here.
Abstract

Previous studies of natural variants in implicated the Wnt signaling receptor in sleep. Given that the Wnt signaling pathway is highly conserved across species, we hypothesized that (), the murine homolog of , would also have a role in sleep. Using a CRISPR transgenic approach, we removed most of the coding region from C57BL/6N mice. We used a video assay to measure sleep characteristics in -deficient mice. As signaling is known to affect visuospatial memory, we also examined the impact of the deletion on learning and memory using the novel object recognition (NOR) paradigm. -deficient mice had altered sleep compared to littermate controls. The mice did not respond differently to the NOR paradigm compared to controls but did display anxiety-like behavior. Our strategy demonstrates that the study of natural variation in sleep translates into candidate genes for sleep in vertebrate species such as the mouse.

Citing Articles

Orthologs of and impact sleep in mice.

Harbison S, Peiravi M, Zhang F, Yimam S, Noguchi A, Springer D Sleep Adv. 2024; 5(1):zpae092.

PMID: 39737163 PMC: 11683587. DOI: 10.1093/sleepadvances/zpae092.


Evo-devo applied to sleep research: an approach whose time has come.

Brown R Sleep Adv. 2024; 5(1):zpae040.

PMID: 39022590 PMC: 11253433. DOI: 10.1093/sleepadvances/zpae040.

References
1.
Marzo A, Galli S, Lopes D, McLeod F, Podpolny M, Segovia-Roldan M . Reversal of Synapse Degeneration by Restoring Wnt Signaling in the Adult Hippocampus. Curr Biol. 2016; 26(19):2551-2561. PMC: 5070786. DOI: 10.1016/j.cub.2016.07.024. View

2.
Ennaceur A . One-trial object recognition in rats and mice: methodological and theoretical issues. Behav Brain Res. 2010; 215(2):244-54. DOI: 10.1016/j.bbr.2009.12.036. View

3.
Shafer O, Keene A . The Regulation of Drosophila Sleep. Curr Biol. 2021; 31(1):R38-R49. DOI: 10.1016/j.cub.2020.10.082. View

4.
Van Buskirk C, Sternberg P . Epidermal growth factor signaling induces behavioral quiescence in Caenorhabditis elegans. Nat Neurosci. 2007; 10(10):1300-7. DOI: 10.1038/nn1981. View

5.
Bushey D, Huber R, Tononi G, Cirelli C . Drosophila Hyperkinetic mutants have reduced sleep and impaired memory. J Neurosci. 2007; 27(20):5384-93. PMC: 6672338. DOI: 10.1523/JNEUROSCI.0108-07.2007. View