Cinnamomi Cortex Extract Mitigated Monosodium Urate-induced Acute Gouty Arthritis in Rats Through Nuclear Factor-κB-NOD-like Receptor Thermal Protein Domain Associated Protein 3 Signaling Pathway

Overview

Journal J Vet Med Sci

Specialty Veterinary Medicine

Date 2023 Nov 29

PMID 38030283

Authors

Gengpeng Zhang

Yuejia Lin

Xianhua Chen

Jian Qin

Yuhai He

Taoli Liu

Li Zhang

Lu Zhang

Affiliations

Soon will be listed here.

Abstract

Cinnamomi cortex was applied to mitigate joint injury since ancient China. However, the effect of Cinnamomi cortex on gouty arthritis (GA) was rarely reported. This study aimed to explore the effect of Cinnamomi cortex on monosodium urate (MSU)-induced acute GA (AGA) in rats, and clarify the underlying mechanism. The results showed that Cinnamomi cortex extract (CE) containing rich polyphenols and flavonoids alleviated joint swelling and inflammation by reducing programmed cell death in MSU-induced AGA rats. Network pharmacology analysis showed that CE's predictive inflammatory pathways included nuclear factor-κB (NF-κB) and necroptosis pathways. CE reduced expression of pyroptosis-related regulators including Gasdermin D and Caspase 1 via regulating NF-κB/NOD-like receptor thermal protein domain associated protein 3 signaling pathway in AGA rats. In conclusion, this study provided a theoretical basis for Cinnamomi cortex applied as a new veterinary medicine to protect against GA.

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