Silver Nanoparticles and Graphene Oxide Complex As an Anti-Inflammatory Biocompatible Liquid Nano-Dressing for Skin Infected with

Overview

Journal J Inflamm Res

Publisher Dove Medical Press

Date 2023 Nov 29

PMID 38026239

Authors

Marlena Zielinska-Gorska

Malwina Sosnowska-Lawnicka

Slawomir Jaworski

Agata Lange

Karolina Daniluk

Barbara Nasilowska

Bartosz Bartosewicz

Andre Chwalibog

Ewa Sawosz

Affiliations

Soon will be listed here.

Abstract

Background: Bacterial skin infections, including , are a powerful and still not fully resolved problem. The aim of this research was to determine the possibility of using a complex of graphene oxide (GO) encrusted with silver nanoparticles as an effective antibacterial agent against and to assess its pro-inflammatory properties.

Methods: The tests were carried out in vitro on EpiDerm™ Skin, an artificial skin model (MatTek in vitro Life Science Laboratories, Slovak Republic), and the fibroblast cell line (HFF-2 from ATCC, USA). Both models were infected with bacteria (ATCC 25923) and then treated with antibiotics or our experimental factors: silver nanoparticles (AgNPs, Nano-koloid, Poland), graphene oxide (GO, NanoPoz, Poland), and complex AgNP-GO (hydrocolloid created by self-assembly).

Results: The antibacterial effectiveness of the AgNP-GO complex was equivalent to that of the antibiotic. In addition, an increase in the level of pro-inflammatory cytokines was observed under the influence of antibiotic administration, in contrast to the effect of AgNP-GO, which showed very limited pro-inflammatory activity.

Conclusion: Hydrocolloid of the AgNP-GO complex, administered in the form of a liquid dressing, may act as an antibacterial agent and also reduce inflammation induced by infection.

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