Management of Comorbidities in Difficult and Severe Asthma

Overview

Journal Breathe (Sheff)

Specialty Pulmonary Medicine

Date 2023 Nov 29

PMID 38020342

Authors

Jehangir Khan

Barry Moran

Cormac McCarthy

Marcus W Butler

Alessandro N Franciosi

Affiliations

Soon will be listed here.

Abstract

Difficult-to-treat and severe asthma are challenging clinical entities. In the face of suboptimal asthma control, the temptation for clinicians is to reflexively escalate asthma-directed therapy, including increasing exposure to corticosteroids and commencement of costly but potent biologic therapies. However, asthma control is objectively and subjectively assessed based on measurable parameters (such as exacerbations or variability in pulmonary physiology), symptoms and patient histories. Crucially, these features can be confounded by common untreated comorbidities, affecting clinicians' assessment of asthma treatment efficacy.

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