Long-Acting Ocular Injectables: Are We Looking In The Right Direction?

Overview

Journal Adv Sci (Weinh)

Specialty Biomedical Engineering

Date 2023 Nov 29

PMID 38018313

Authors

Mickael Dang

Molly S Shoichet

Affiliations

Soon will be listed here.

Abstract

The complex anatomy and physiological barriers of the eye make delivering ocular therapeutics challenging. Generally, effective drug delivery to the eye is hindered by rapid clearance and limited drug bioavailability. Biomaterial-based approaches have emerged to enhance drug delivery to ocular tissues and overcome existing limitations. In this review, some of the most promising long-acting injectables (LAIs) in ocular drug delivery are explored, focusing on novel design strategies to improve therapeutic outcomes. LAIs are designed to enable sustained therapeutic effects, thereby extending local drug residence time and facilitating controlled and targeted drug delivery. Moreover, LAIs can be engineered to enhance drug targeting and penetration across ocular physiological barriers.

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Long-Acting Ocular Injectables: Are We Looking In The Right Direction?.

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