Oxidative Stress Regulation and Related Metabolic Pathways in Epithelial-mesenchymal Transition of Breast Cancer Stem Cells

Overview

Journal Stem Cell Res Ther

Publisher Biomed Central

Date 2023 Nov 29

PMID 38017510

Authors

Raheleh Farahzadi

Behnaz Valipour

Ezzatollah Fathi

Samaneh Pirmoradi

Ommoleila Molavi

Soheila Montazersaheb

Zohreh Sanaat

Affiliations

Soon will be listed here.

Abstract

Epithelial-mesenchymal transition (EMT) is a cell remodeling process in which epithelial cells undergo a reversible phenotype switch via the loss of adhesion capacity and acquisition of mesenchymal characteristics. In other words, EMT activation can increase invasiveness and metastatic properties, and prevent the sensitivity of tumor cells to chemotherapeutics, as mesenchymal cells have a higher resistance to chemotherapy and immunotherapy. EMT is orchestrated by a complex and multifactorial network, often linked to episodic, transient, or partial events. A variety of factors have been implicated in EMT development. Based on this concept, multiple metabolic pathways and master transcription factors, such as Snail, Twist, and ZEB, can drive the EMT. Emerging evidence suggests that oxidative stress plays a significant role in EMT induction. One emerging theory is that reducing mitochondrial-derived reactive oxygen species production may contribute to EMT development. This review describes how metabolic pathways and transcription factors are linked to EMT induction and addresses the involvement of signaling pathways.

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