Antioxidant Effects of Phenolic Compounds in Through the Distillation of Lonicera Japonica & Chenpi Extract and Anti-inflammation on Skin Keratinocyte

Overview

Journal Sci Rep

Specialty Science

Date 2023 Nov 28

PMID 38016995

Authors

Hun Hwan Kim

Se Hyo Jeong

Min Yeong Park

Pritam Bhangwan Bhosale

Abuyaseer Abusaliya

Hyun Wook Kim

Je Kyung Seong

Meejung Ahn

Kwang Il Park

Gon Sup Kim

Affiliations

Soon will be listed here.

Abstract

The phenolic compounds in Lonicera japonica & Chenpi distillation extract (LCDE) were thoroughly examined for their antioxidant and anti-inflammatory properties. Phenolic compounds in LCDE were analyzed for five peaks using high-performance liquid chromatography (HPLC) combined with mass spectrometry (MS) and determined. Five phenolic compounds were identified from the samples and MS data. Ultrafiltration with LC analysis was used to investigate the ability of bioactive compounds to target DPPH. As a result, it was confirmed that the major compounds exhibited a high binding affinity to DPPH and could be regarded as antioxidant-active compounds. In addition, the anti-inflammatory effect of LCDE was confirmed in vitro, and signal inhibition of anti-inflammation cytokines, MAPK and NF-kB pathways was confirmed. Finally, Molecular docking analysis supplements the anti-inflammatory effect through the binding affinity of selected compounds and inflammatory factors. In conclusion, the phenolic compounds of the LCDE were identified and potential active compounds for antioxidant and anti-inflammatory activities were identified. Additionally, this study will be utilized to provide basic information for the application of LCDE in the pharmaceutical and pharmaceutical cosmetics industries along with information on efficient screening techniques for other medicinal plants.

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