Propagation Through Electrically Coupled Cells. How a Small SA Node Drives a Large Atrium

Overview

Journal Biophys J

Publisher Cell Press

Specialty Biophysics

Date 1986 Dec 1

PMID 3801575

Citations 62

Authors

R W Joyner

F J van Capelle

Affiliations

Soon will be listed here.

Abstract

Each normal cardiac cycle is started by an action potential that is initiated in the sino-atrial (SA) node by automaticity of the SA nodal cells. This action potential then propagates from the SA node into the surrounding atrial cells. We have done numerical simulations of electrically coupled cells to understand how a small SA node can be spontaneously active and yet be sufficiently electrically coupled to the surrounding quiescent atrial cells to initiate an action potential in the atrial cells. Our results with a simple model of two coupled cells and a more complex model of a two-dimensional sheet of cells suggest that some degree of electrical uncoupling of the cells within the SA node may be an essential design feature of the normal SA-atrial system.

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References

Joyner R, Ramon F, Morre J . Simulation of action potential propagation in an inhomogeneous sheet of coupled excitable cells. Circ Res. 1975; 36(5):654-61. DOI: 10.1161/01.res.36.5.654. View

Weingart R . Electrical properties of the nexal membrane studied in rat ventricular cell pairs. J Physiol. 1986; 370:267-84. PMC: 1192680. DOI: 10.1113/jphysiol.1986.sp015934. View

BEELER G, Reuter H . Reconstruction of the action potential of ventricular myocardial fibres. J Physiol. 1977; 268(1):177-210. PMC: 1283659. DOI: 10.1113/jphysiol.1977.sp011853. View

Joyner R, Westerfield M, Moore J, Stockbridge N . A numerical method to model excitable cells. Biophys J. 1978; 22(2):155-70. PMC: 1473438. DOI: 10.1016/S0006-3495(78)85481-2. View

Masson-Pevet M, Bleeker W, Gros D . The plasma membrane of leading pacemaker cells in the rabbit sinus node. A qualitative and quantitative ultrastructural analysis. Circ Res. 1979; 45(5):621-9. DOI: 10.1161/01.res.45.5.621. View

Clapham D, Shrier A, Dehaan R . Junctional resistance and action potential delay between embryonic heart cell aggregates. J Gen Physiol. 1980; 75(6):633-54. PMC: 2215265. DOI: 10.1085/jgp.75.6.633. View

Mackaay A, Opt Hof T, Bleeker W, Jongsma H, BOUMAN L . Interaction of adrenaline and acetylcholine on cardiac pacemaker function. Functional inhomogeneity of the rabbit sinus node. J Pharmacol Exp Ther. 1980; 214(2):417-22. View

Sharp G, Joyner R . Simulated propagation of cardiac action potentials. Biophys J. 1980; 31(3):403-23. PMC: 1328799. DOI: 10.1016/S0006-3495(80)85068-5. View

Bleeker W, Mackaay A, Masson-Pevet M, Opt Hof T, Jongsma H, BOUMAN L . Asymmetry of the sino-atrial conduction in the rabbit heart. J Mol Cell Cardiol. 1982; 14(11):633-43. DOI: 10.1016/0022-2828(82)90161-4. View

10.

Joyner R, Picone J, Veenstra R, Rawling D . Propagation through electrically coupled cells. Effects of regional changes in membrane properties. Circ Res. 1983; 53(4):526-34. DOI: 10.1161/01.res.53.4.526. View

11.

Joyner R, Overholt E, Ramza B, Veenstra R . Propagation through electrically coupled cells: two inhomogeneously coupled cardiac tissue layers. Am J Physiol. 1984; 247(4 Pt 2):H596-609. DOI: 10.1152/ajpheart.1984.247.4.H596. View

12.

Jalife J . Mutual entrainment and electrical coupling as mechanisms for synchronous firing of rabbit sino-atrial pace-maker cells. J Physiol. 1984; 356:221-43. PMC: 1193160. DOI: 10.1113/jphysiol.1984.sp015461. View

13.

Kodama I, Boyett M . Regional differences in the electrical activity of the rabbit sinus node. Pflugers Arch. 1985; 404(3):214-26. DOI: 10.1007/BF00581242. View

14.

White R, Spray D, De Carvalho A, Wittenberg B, Bennett M . Some electrical and pharmacological properties of gap junctions between adult ventricular myocytes. Am J Physiol. 1985; 249(5 Pt 1):C447-55. DOI: 10.1152/ajpcell.1985.249.5.C447. View

15.

Veenstra R, Dehaan R . Electrotonic interactions between aggregates of chick embryo cardiac pacemaker cells. Am J Physiol. 1986; 250(3 Pt 2):H453-63. DOI: 10.1152/ajpheart.1986.250.3.H453. View

16.

Moore J, Ramon F, Joyner R . Axon voltage-clamp simulations. I. Methods and tests. Biophys J. 1975; 15(1):11-24. PMC: 1334607. DOI: 10.1016/S0006-3495(75)85788-2. View