A Bayesian Proportional Hazards Mixture Cure Model for Interval-censored Data

Overview

Journal Lifetime Data Anal

Publisher Springer

Date 2023 Nov 28

PMID 38015378

Authors

Chun Pan

Bo Cai

Xuemei Sui

Affiliations

Soon will be listed here.

Abstract

The proportional hazards mixture cure model is a popular analysis method for survival data where a subgroup of patients are cured. When the data are interval-censored, the estimation of this model is challenging due to its complex data structure. In this article, we propose a computationally efficient semiparametric Bayesian approach, facilitated by spline approximation and Poisson data augmentation, for model estimation and inference with interval-censored data and a cure rate. The spline approximation and Poisson data augmentation greatly simplify the MCMC algorithm and enhance the convergence of the MCMC chains. The empirical properties of the proposed method are examined through extensive simulation studies and also compared with the R package "GORCure". The use of the proposed method is illustrated through analyzing a data set from the Aerobics Center Longitudinal Study.

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