Comparison of Early Wound Healing Using Modified Papilla Preservation Technique Between Enamel Matrix Derivative and Recombinant Human Fibroblast Growth Factor

Overview

Journal J Periodontal Implant Sci

Specialty Dentistry

Date 2023 Nov 28

PMID 38014774

Authors

Yohei Nakayama

Shinichi Tabe

Kazuma Igarashi

Satoshi Moriya

Tsuyoshi Katsumata

Ryo Kobayashi

Shuta Nakagawa

Tomoko Nishino

Namiko Fukuoka

Kota Hosono

Mai Yamasaki

Yosuke Yamazaki

Moe Ogihara-Takeda

Shoichi Ito

Yumi Saito

Arisa Yamaguchi

Yuto Tsuruya

Mizuho Yamazaki-Takai

Shoichi Yoshino

Hideki Takai

Yorimasa Ogata

Affiliations

Soon will be listed here.

Abstract

Purpose: Enamel matrix derivative (EMD) has demonstrated beneficial effects on wound healing following surgery. However, the effects of recombinant human fibroblast growth factor 2 (rhFGF-2) in periodontal regeneration therapy have not been extensively studied. This retrospective study was conducted to compare the wound healing outcomes of the modified papilla preservation technique (mPPT) between EMD and rhFGF-2 therapies.

Methods: A total of 79 sites were evaluated for early wound healing using the modified early wound healing index (mEHI), which included 6 items: incision, fibrin clotting, step, redness, swelling, and dehiscence. A numeric analog scale, along with postoperative images of the 6 mEHI items, was established and used for the evaluations. The inter-rater reliability of the mEHI was assessed via intraclass correlation coefficients (ICCs). After adjusting for factors influencing the mPPT, the differences in mEHI scores between the EMD and rhFGF-2 groups were statistically analyzed. Additionally, radiographic bone fill (RBF) was evaluated 6 months after surgery.

Results: The ICC of the mEHI was 0.575. The mEHI, redness score, and dehiscence scores were significantly higher in the rhFGF-2 group (n=33) than in the EMD group (n=46). Similar results were observed in the subgroup of patients aged 50 years or older, but not in those younger than 50 years. In the subgroup with non-contained bone defects, related results were noted, but not in the subgroup with contained bone defects. However, early wound healing did not correlate with RBF at 6 months after surgery.

Conclusions: Within the limitations of this study, the findings suggest that early wound healing following the use of mPPT with rhFGF-2 is somewhat superior to that observed after mPPT with EMD. However, mEHI should be improved for use as a predictive tool for early wound healing and to reflect clinical outcomes after surgery.

Citing Articles

[Analysis of soft tissue healing after keratinized tissue augmentation in reconstructed jaws].

Nie J, Dong J, Lu R Beijing Da Xue Xue Bao Yi Xue Ban. 2025; 57(1):57-64.

PMID: 39856507 PMC: 11759810.

Early wound healing at 1 week postoperatively in periodontal tissue regeneration therapy: enamel matrix derivative versus recombinant human fibroblast growth factor.

Nakayama Y, Ogihara-Takeda M, Saito Y, Yamaguchi A, Ogata Y J Periodontal Implant Sci. 2024; 54(6):405-418.

PMID: 39058346 PMC: 11729240. DOI: 10.5051/jpis.2400740037.

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