Hydration and the Lamellar to Hexagonal II Phase Transition of Phosphatidylethanolamine

Overview

Journal Biochemistry

Specialty Biochemistry

Date 1986 Nov 18

PMID 3801431

Citations 16

Authors

P L Yeagle

A Sen

Affiliations

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Abstract

The effects of chaotropic agents on the lamellar to hexagonal II phase transition of soy phosphatidylethanolamine were examined. Guanidine hydrochloride, urea, and NaSCN were used as chaotropic agents. In each case, the lamellar phase was stabilized by the presence of the chaotropic agent. In the case of NaSCN, the temperature of the lamellar to hexagonal phase transition of soy phosphatidylethanolamine was increased by more than 60 degrees C. Guanidine hydrochloride was capable of substantially reducing the aggregation of phosphatidylethanolamine vesicles. These data lead to a thermodynamic understanding of the lamellar to hexagonal phase transition.

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