Tuberculosis Infection Control Practice Among Healthcare Workers in Ethiopia: a Protocol for Systematic Review and Meta-analysis

Overview

Journal BMJ Open

Specialty General Medicine

Date 2023 Nov 27

PMID 38011970

Authors

Misganaw Guadie Tiruneh

Tadele Fentabil Anagaw

Eneyew Talie Fenta

Affiliations

Soon will be listed here.

Abstract

Background: Tuberculosis (TB) is a main concern of health care workers in sub-Saharan Africa. Healthcare workers have the potential to have contact with TB patients and are the main stakeholders in healthcare settings to implement TB infection control, and the poor practice of TB infection control may increase the risk of transmission of TB in healthcare settings. However, there is no consistent conclusion on the TB infection control practice among healthcare workers in Ethiopia. Thus, this study aimed to determine the pooled magnitude of TB infection control practice and associated factors among healthcare workers in Ethiopia.

Methods: This systematic review and meta-analysis will be done by following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline. The following databases will be used to search for articles: PubMed, Cochrane Library, Google Scholar and grey literatures. The quality of studies will be assessed using the Joanna Briggs Institute (JBI) critical appraisal checklist. The data from included studies will be extracted using Microsoft Excel V.2016, and the extracted data will be analysed using STATA V.16. Forest plot and I statistics will be done for heterogeneity. A funnel plot and Egger's regression test will be conducted to check for publication bias. Potential sources of bias will be identified by subgroup analysis and meta-regression. Any type of study design conducted in Ethiopia and in English language will be included.

Ethics And Dissemination: Ethics approval is not required, and the findings will be published in peer-reviewed journal.

Prospero Registration Number: CRD42023393580.

References

Alele F, Franklin R, Emeto T, Leggat P . Occupational tuberculosis in healthcare workers in sub-Saharan Africa: A systematic review. Arch Environ Occup Health. 2018; 74(3):95-108. DOI: 10.1080/19338244.2018.1461600. View

Labena F, Kassa Y, Gambura E . Tuberculosis and Public Health Care Workers: Infection Prevention and Control Practices and Associated Factors Among Governmental Health Centers and Hospitals in Wolaita Zone, Southern Ethiopia. J Multidiscip Healthc. 2021; 14:2111-2122. PMC: 8364355. DOI: 10.2147/JMDH.S321592. View

Tenna A, Stenehjem E, Margoles L, Kacha E, Blumberg H, Kempker R . Infection control knowledge, attitudes, and practices among healthcare workers in Addis Ababa, Ethiopia. Infect Control Hosp Epidemiol. 2013; 34(12):1289-96. PMC: 3995333. DOI: 10.1086/673979. View

Nasreen S, Shokoohi M, Malvankar-Mehta M . Prevalence of Latent Tuberculosis among Health Care Workers in High Burden Countries: A Systematic Review and Meta-Analysis. PLoS One. 2016; 11(10):e0164034. PMC: 5053544. DOI: 10.1371/journal.pone.0164034. View

Alene K, Adane A, Yifiru S, Bitew B, Adane A, Koye D . Knowledge and practice of health workers about control and prevention of multidrug-resistant tuberculosis in referral hospitals, Ethiopia: a cross-sectional study. BMJ Open. 2019; 9(2):e022948. PMC: 6368005. DOI: 10.1136/bmjopen-2018-022948. View

Temesgen C, Demissie M . Knowledge and practice of tuberculosis infection control among health professionals in Northwest Ethiopia; 2011. BMC Health Serv Res. 2014; 14:593. PMC: 4240849. DOI: 10.1186/s12913-014-0593-2. View

Rutanga C, Lowrance D, Oeltmann J, Mutembayire G, Willis M, Uwizeye C . Latent Tuberculosis Infection and Associated Factors among Health Care Workers in Kigali, Rwanda. PLoS One. 2015; 10(4):e0124485. PMC: 4412475. DOI: 10.1371/journal.pone.0124485. View

Grobler L, Mehtar S, Dheda K, Adams S, Babatunde S, Van Der Walt M . The epidemiology of tuberculosis in health care workers in South Africa: a systematic review. BMC Health Serv Res. 2016; 16(1):416. PMC: 4992336. DOI: 10.1186/s12913-016-1601-5. View

Tudor C, Van Der Walt M, Margot B, Dorman S, Pan W, Yenokyan G . Tuberculosis among health care workers in KwaZulu-Natal, South Africa: a retrospective cohort analysis. BMC Public Health. 2014; 14:891. PMC: 4161912. DOI: 10.1186/1471-2458-14-891. View

10.

Tamir K, Wasie B, Azage M . Tuberculosis infection control practices and associated factors among health care workers in health centers of West Gojjam zone, Northwest Ethiopia: a cross-sectional study. BMC Health Serv Res. 2016; 16(a):359. PMC: 4977729. DOI: 10.1186/s12913-016-1608-y. View

11.

Uden L, Barber E, Ford N, Cooke G . Risk of Tuberculosis Infection and Disease for Health Care Workers: An Updated Meta-Analysis. Open Forum Infect Dis. 2017; 4(3):ofx137. PMC: 5575844. DOI: 10.1093/ofid/ofx137. View

12.

Tadesse A, Alagaw A, Kassa M, Bekele M . Tuberculosis infection control practices and associated factors among healthcare workers in hospitals of Gamo Gofa Zone, Southern Ethiopia, institution-based cross-sectional study. PLoS One. 2020; 15(9):e0239159. PMC: 7505450. DOI: 10.1371/journal.pone.0239159. View

13.

Ayalew A, Gashu Z, Anteneh T, Hiruy N, Habte D, Jerene D . Improvement in tuberculosis infection control practice via technical support in two regions of Ethiopia. BMC Infect Dis. 2018; 18(1):557. PMC: 6233357. DOI: 10.1186/s12879-018-3459-0. View

14.

Wang X, He T, Geng M, Song Y, Wang J, Liu M . Prevalence of and risk factors for tuberculosis among healthcare workers in Chinese tuberculosis facilities. Infect Dis Poverty. 2018; 7(1):26. PMC: 5872547. DOI: 10.1186/s40249-018-0407-6. View

15.

Agaya J, Nnadi C, Odhiambo J, Obonyo C, Obiero V, Lipke V . Tuberculosis and latent tuberculosis infection among healthcare workers in Kisumu, Kenya. Trop Med Int Health. 2015; 20(12):1797-804. DOI: 10.1111/tmi.12601. View

16.

Sterne J, Egger M . Funnel plots for detecting bias in meta-analysis: guidelines on choice of axis. J Clin Epidemiol. 2001; 54(10):1046-55. DOI: 10.1016/s0895-4356(01)00377-8. View

17.

Gizaw G, Alemu Z, Kibret K . Assessment of knowledge and practice of health workers towards tuberculosis infection control and associated factors in public health facilities of Addis Ababa, Ethiopia: A cross-sectional study. Arch Public Health. 2015; 73(1):15. PMC: 4377015. DOI: 10.1186/s13690-015-0062-3. View

18.

Masresha S, Alen G, Kidie A, Dessie A, Dejene T . First line antiretroviral treatment failure and its association with drug substitution and sex among children in Ethiopia: systematic review and meta-analysis. Sci Rep. 2022; 12(1):18294. PMC: 9622840. DOI: 10.1038/s41598-022-22237-6. View