Role of Epithelial-mesenchymal Transition Factor SNAI1 and Its Targets in Ovarian Cancer Aggressiveness

Overview

Journal J Cancer Metastasis Treat

Date 2023 Nov 27

PMID 38009093

Authors

Tise Suzuki

Ashlyn Conant

Casey Curow

Audrey Alexander

Yevgeniya Ioffe

Juli J Unternaehrer

Affiliations

Soon will be listed here.

Abstract

Ovarian cancer remains the most lethal gynecologic malignancy in the USA. For over twenty years, epithelial-mesenchymal transition (EMT) has been characterized extensively in development and disease. The dysregulation of this process in cancer has been identified as a mechanism by which epithelial tumors become more aggressive, allowing them to survive and invade distant tissues. This occurs in part due to the increased expression of the EMT transcription factor, (Snail). In the case of epithelial ovarian cancer, Snail has been shown to contribute to cancer invasion, stemness, chemoresistance, and metabolic changes. Thus, in this review, we focus on summarizing current findings on the role of EMT (specifically, factors downstream of Snail) in determining ovarian cancer aggressiveness.

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