Adolescent Neurodevelopment Within the Context of Impulsivity and Substance Use

Overview

Journal Curr Addict Rep

Date 2023 Nov 27

PMID 38009082

Authors

ReJoyce Green

Lindsay R Meredith

Louise Mewton

Lindsay M Squeglia

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: The aim of the present review is to provide an update on recent studies examining adolescent neurodevelopment in the context of impulsivity and substance use. We provide a review of the neurodevelopmental changes in brain structure and function related to impulsivity, substance use, and their intersection.

Recent Findings: When examining brain structure, smaller gray matter volume coupled with lower white matter integrity is associated with greater impulsivity across three components: trait impulsivity, choice impulsivity, and response inhibition. Altered functional connectivity in networks including the inhibitory control network and reward processing network confers risk for greater impulsivity and substance use.

Summary: Across brain structure and function, there is evidence to suggest that overlapping areas involved in the rise in impulsivity during adolescence contribute to early substance use initiation and escalation. These overlapping neurodevelopmental correlates have promising implications for prevention and early intervention efforts for adolescent substance use.

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