Pseudocarcinomatous Hyperplasia of the Nose and Necrotic Tracheitis Associated with Acute Myeloid Leukemia

Overview

Journal Intern Med

Specialty General Medicine

Date 2023 Nov 26

PMID 38008455

Authors

Shigehisa Kajikawa

Satsuki Murakami

Akiyoshi Takami

Akira Satou

Toyonori Tsuzuki

Tomoyuki Ogisu

Toshiyuki Yonezawa

Hiroyuki Tanaka

Akihito Kubo

Satoru Ito

Affiliations

Soon will be listed here.

Abstract

A 29-year-old woman who had been diagnosed with acute myeloid leukemia presented with persistent grade-4 febrile neutropenia (FN) after initial chemotherapy with idarubicin and cytarabine. Despite intensive treatment, FN persisted. Subsequently, her nose became reddish and swollen, obstructing the nasal cavities. Computed tomography revealed swelling of the nostrils and an irregular tracheal surface. Debridement of the nasal lesion and a bronchoscopic biopsy of the tracheal lesion were also performed. A histopathological examination revealed pseudocarcinomatous hyperplasia (PCH) of the nose and necrotizing tracheitis. Both nasal PCH and necrotizing tracheitis ameliorated when the patient recovered from leukocytopenia.

References

CIVATTE J . Pseudo-carcinomatous hyperplasia. J Cutan Pathol. 1985; 12(3-4):214-23. DOI: 10.1111/j.1600-0560.1985.tb01624.x. View

Yoshino N, Kimura S, Matsuoka A, Meno T, Ishikawa T, Nakamura Y . Clinical features of febrile neutropenia and bloodstream infection in autologous hematopoietic cell transplantation: Comparison to those in intensive chemotherapy for acute myeloid leukemia. J Infect Chemother. 2023; 29(4):384-390. DOI: 10.1016/j.jiac.2023.01.004. View

Jeunon T, Assoni A, Verdolin A . Pseudocarcinomatous Hyperplasia, Squamous Cell Carcinoma, and Keratoacanthoma Associated to Lymphomas of the Skin and External Mucous Membranes: A Case Report and Literature Review. Am J Dermatopathol. 2019; 42(9):662-672. DOI: 10.1097/DAD.0000000000001587. View

Franquet T, Serrano F, Gimenez A, Rodriguez-Arias J, Puzo C . Necrotizing Aspergillosis of large airways: CT findings in eight patients. J Comput Assist Tomogr. 2002; 26(3):342-5. DOI: 10.1097/00004728-200205000-00004. View

Kajikawa S, Noda K, Nozaki Y . Necrotizing tracheobronchitis associated with rheumatoid arthritis. Respir Med Case Rep. 2016; 20:31-33. PMC: 5121158. DOI: 10.1016/j.rmcr.2016.11.006. View

Takahashi S, Nakamura M . Necrotizing tracheobronchitis caused by influenza and Staphylococcus aureus co-infection. Infection. 2018; 46(5):737-739. DOI: 10.1007/s15010-018-1180-y. View

Wipf A, Wipf H, Miller D . Sweet syndrome with pseudocarcinomatous hyperplasia: A case report and review of the literature. J Cutan Pathol. 2019; 46(7):520-527. DOI: 10.1111/cup.13436. View

Chechani V, Vasudevan V, Kamholz S . Necrotizing tracheobronchitis: complication of mechanical ventilation in an adult. South Med J. 1991; 84(2):271-3. View

Grunwald M, Lee J, Ackerman A . Pseudocarcinomatous hyperplasia. Am J Dermatopathol. 1988; 10(2):95-103. DOI: 10.1097/00000372-198804000-00001. View

10.

Shah K, Kazlouskaya V, Lal K, Molina D, Elston D . Perforating elastic fibers ('elastic fiber trapping') in the differentiation of keratoacanthoma, conventional squamous cell carcinoma and pseudocarcinomatous epithelial hyperplasia. J Cutan Pathol. 2013; 41(2):108-12. DOI: 10.1111/cup.12247. View

11.

Wang C, Pusic I, Anadkat M . Association of Leukemia Cutis With Survival in Acute Myeloid Leukemia. JAMA Dermatol. 2019; 155(7):826-832. PMC: 6583862. DOI: 10.1001/jamadermatol.2019.0052. View

12.

Lukach A, Han J, Gardeen S, English 3rd J, Rosenman K, Speetzen L . Pseudocarcinomatous Sweet syndrome. JAAD Case Rep. 2022; 26:73-75. PMC: 9343922. DOI: 10.1016/j.jdcr.2022.06.010. View

13.

SWEET R . AN ACUTE FEBRILE NEUTROPHILIC DERMATOSIS. Br J Dermatol. 1964; 76:349-56. DOI: 10.1111/j.1365-2133.1964.tb14541.x. View

14.

El-Khoury J, Kibbi A, Abbas O . Mucocutaneous pseudoepitheliomatous hyperplasia: a review. Am J Dermatopathol. 2011; 34(2):165-75. DOI: 10.1097/DAD.0b013e31821816ab. View

15.

Le X, Jain P, OBrien S . Aspergillus pseudomembranous necrotizing tracheitis. Am J Hematol. 2012; 88(3):242. DOI: 10.1002/ajh.23332. View

16.

Osmanski 2nd J, Fraire A, Schaefer O . Necrotizing tracheobronchitis with progressive airflow obstruction associated with paraneoplastic pemphigus. Chest. 1997; 112(6):1704-7. DOI: 10.1378/chest.112.6.1704. View