Lymphangioleiomyomatosis Showing the Development of Mycobacterium Abscessus Subsp. Massiliense Infection During Sirolimus Therapy

Overview

Journal Intern Med

Specialty General Medicine

Date 2023 Nov 26

PMID 38008448

Authors

Atsushi Yanagisawa

Takayuki Takimoto

Yu Kurahara

Kazunari Tsuyuguchi

Shiomi Yoshida

Masaki Hirose

Yoshikazu Inoue

Toru Arai

Affiliations

Soon will be listed here.

Abstract

Among nontuberculous mycobacterial pulmonary diseases (NTM-PDs), Mycobacterium abscessus species pulmonary disease (MABS-PD) is one of the most severe and intractable infections. We herein report a 45-year-old woman with advanced lymphangioleiomyomatosis (LAM) who developed MABS-PD while undergoing sirolimus therapy. MABS-PD was immediately controlled using antibiotic therapy, although the patient's lung transplant registration was significantly delayed. To our knowledge, this is the first case report on the development of NTM-PD in a patient with LAM before lung transplantation. This case suggests that the early diagnosis and optimal treatment of NTM-PD are crucial in patients with advanced LAM.

References

Morimoto K, Iwai K, Uchimura K, Okumura M, Yoshiyama T, Yoshimori K . A steady increase in nontuberculous mycobacteriosis mortality and estimated prevalence in Japan. Ann Am Thorac Soc. 2013; 11(1):1-8. DOI: 10.1513/AnnalsATS.201303-067OC. View

Koh W, Stout J, Yew W . Advances in the management of pulmonary disease due to Mycobacterium abscessus complex. Int J Tuberc Lung Dis. 2014; 18(10):1141-8. DOI: 10.5588/ijtld.14.0134. View

Floto R, Sarkar S, Perlstein E, Kampmann B, Schreiber S, Rubinsztein D . Small molecule enhancers of rapamycin-induced TOR inhibition promote autophagy, reduce toxicity in Huntington's disease models and enhance killing of mycobacteria by macrophages. Autophagy. 2007; 3(6):620-2. DOI: 10.4161/auto.4898. View

Dos Anjos L, Parreira P, Torres P, Kipnis A, Junqueira-Kipnis A, Rabahi M . Non-tuberculous mycobacterial lung disease: a brief review focusing on radiological findings. Rev Soc Bras Med Trop. 2020; 53:e20200241. PMC: 7491562. DOI: 10.1590/0037-8682-0241-2020. View

Friedman D, Cervera C, Halloran K, Tyrrell G, Doucette K . Non-tuberculous mycobacteria in lung transplant recipients: Prevalence, risk factors, and impact on survival and chronic lung allograft dysfunction. Transpl Infect Dis. 2019; 22(2):e13229. DOI: 10.1111/tid.13229. View

Greenstein R, Su L, Juste R, Brown S . On the action of cyclosporine A, rapamycin and tacrolimus on M. avium including subspecies paratuberculosis. PLoS One. 2008; 3(6):e2496. PMC: 2427180. DOI: 10.1371/journal.pone.0002496. View

Thomson A, Turnquist H, Raimondi G . Immunoregulatory functions of mTOR inhibition. Nat Rev Immunol. 2009; 9(5):324-37. PMC: 2847476. DOI: 10.1038/nri2546. View

Chernenko S, Humar A, Hutcheon M, Chow C, Chaparro C, Keshavjee S . Mycobacterium abscessus infections in lung transplant recipients: the international experience. J Heart Lung Transplant. 2006; 25(12):1447-55. DOI: 10.1016/j.healun.2006.09.003. View

Lee M, Sheng W, Hung C, Yu C, Lee L, Hsueh P . Mycobacterium abscessus Complex Infections in Humans. Emerg Infect Dis. 2015; 21(9):1638-46. PMC: 4550155. DOI: 10.3201/2109.141634. View

10.

Goncharova E, Goncharov D, Spaits M, Noonan D, Talovskaya E, Eszterhas A . Abnormal growth of smooth muscle-like cells in lymphangioleiomyomatosis: Role for tumor suppressor TSC2. Am J Respir Cell Mol Biol. 2006; 34(5):561-72. PMC: 2644221. DOI: 10.1165/rcmb.2005-0300OC. View

11.

Takada T, Mikami A, Kitamura N, Seyama K, Inoue Y, Nagai K . Efficacy and Safety of Long-Term Sirolimus Therapy for Asian Patients with Lymphangioleiomyomatosis. Ann Am Thorac Soc. 2016; 13(11):1912-1922. DOI: 10.1513/AnnalsATS.201605-335OC. View

12.

Lewandowska K, Oniszh K, Augustynowicz-Kopec E, Radwan-Rohrenschef P, Kus J . [Bacteriologically confirmed pulmonary tuberculosis in a patient with lymphangioleiomyomatosis accompanying tuberous sclerosis syndrome]. Pneumonol Alergol Pol. 2011; 79(4):309-14. View

13.

Kobayashi T, Tsuyuguchi K, Yoshida S, Kurahara Y, Minomo S, Inoue Y . Serum immunoglobulin a antibodies to glycopeptidolipid core antigen for complex lung disease. Int J Mycobacteriol. 2020; 9(1):76-82. DOI: 10.4103/ijmy.ijmy_14_20. View

14.

Izumi K, Morimoto K, Hasegawa N, Uchimura K, Kawatsu L, Ato M . Epidemiology of Adults and Children Treated for Nontuberculous Mycobacterial Pulmonary Disease in Japan. Ann Am Thorac Soc. 2018; 16(3):341-347. DOI: 10.1513/AnnalsATS.201806-366OC. View

15.

Ripoll F, Deshayes C, Pasek S, Laval F, Beretti J, Biet F . Genomics of glycopeptidolipid biosynthesis in Mycobacterium abscessus and M. chelonae. BMC Genomics. 2007; 8:114. PMC: 1885439. DOI: 10.1186/1471-2164-8-114. View

16.

Noda Y, Shiroyama T, Amiya S, Adachi Y, Enomoto T, Hara R . COVID-19 in a patient with sporadic lymphangioleiomyomatosis awaiting lung transplantation. Respir Med Case Rep. 2021; 34:101505. PMC: 8413486. DOI: 10.1016/j.rmcr.2021.101505. View

17.

McCormack F, Inoue Y, Moss J, Singer L, Strange C, Nakata K . Efficacy and safety of sirolimus in lymphangioleiomyomatosis. N Engl J Med. 2011; 364(17):1595-606. PMC: 3118601. DOI: 10.1056/NEJMoa1100391. View

18.

Namkoong H, Kurashima A, Morimoto K, Hoshino Y, Hasegawa N, Ato M . Epidemiology of Pulmonary Nontuberculous Mycobacterial Disease, Japan. Emerg Infect Dis. 2016; 22(6):1116-7. PMC: 4880076. DOI: 10.3201/eid2206.151086. View

19.

Kitada S, Maekura R, Toyoshima N, Naka T, Fujiwara N, Kobayashi M . Use of glycopeptidolipid core antigen for serodiagnosis of mycobacterium avium complex pulmonary disease in immunocompetent patients. Clin Diagn Lab Immunol. 2005; 12(1):44-51. PMC: 540191. DOI: 10.1128/CDLI.12.1.44-51.2005. View

20.

McCormack F, Travis W, Colby T, Henske E, Moss J . Lymphangioleiomyomatosis: calling it what it is: a low-grade, destructive, metastasizing neoplasm. Am J Respir Crit Care Med. 2012; 186(12):1210-2. PMC: 3622443. DOI: 10.1164/rccm.201205-0848OE. View