Multiscale Biophysical Models of Cardiomyopathies Reveal Complexities Challenging Existing Dogmas

Overview

Journal Biophys J

Publisher Cell Press

Specialty Biophysics

Date 2023 Nov 25

PMID 38006882

Authors

Brent Scott

Michael J Greenberg

Affiliations

Soon will be listed here.

Abstract

Mutations in sarcomeric proteins, including myosin, cause a variety of cardiomyopathies. A prominent hypothesis has been that myosin mutations causing hypercontractility of the motor lead to hypertrophic cardiomyopathy, while those causing hypocontractility lead to dilated cardiomyopathy; however, recent biophysical studies using multiscale computational and experimental models have revealed complexities not captured by this hypothesis. We summarize recent publications in Biophysical Journal challenging this dogma and highlighting the need for multiscale modeling of these complex diseases.

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