Seroprevalence of Hantavirus Among Manual Cane Cutters and Epidemiological Aspects of HPS in Central Brazil

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2023 Nov 25

PMID 38005915

Authors

Renata Malachini Maia

Jorlan Fernandes

Luciana Helena Bassan Vicente de Mattos

Luiz Antonio Bastos Camacho

Karlla Antonieta Amorim Caetano

Megmar Aparecida Dos Santos Carneiro

Fernando de Oliveira Santos

Sheila Araujo Teles

Elba Regina Sampaio de Lemos

Renata Carvalho de Oliveira

Affiliations

Soon will be listed here.

Abstract

Hantavirus pulmonary syndrome (HPS) is a rodent-borne zoonotic disease that is endemic throughout the Americas. Agricultural activities increase exposure to wild rodents, especially for sugarcane cutters. We carried out a survey of the epidemiological aspects of HPS and investigated the prevalence of hantavirus infection in the sugarcane cutter population from different localities in the Brazilian Midwest region. We conducted a retrospective study of all confirmed HPS cases in the state of Goiás reported to the National HPS surveillance system between 2007 and 2017, along with a seroepidemiological study in a population of sugarcane cutters working in Goiás state in 2016, using the anti-hantavirus (Andes) ELISA IgG. A total of 634 serum samples from cane cutters were tested for hantavirus antibodies, with 44 (6.9%) being IgG-reactive according to ELISA. The destination of garbage was the only statistically significant variable ( = 0.03) related to the detection of hantavirus IgG ( < 0.05). We described the epidemiological profile of reported hantavirus cases in Goiás-a highly endemic area for HPS, and where the seroepidemiological study was conducted. Our results increase our knowledge about hantavirus infections in Brazil and highlight the vulnerability of sugarcane cutters to a highly lethal disease that, to date, has no specific treatment or vaccination.

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