» Articles » PMID: 38005826

Immune-Cell-Based Therapy for COVID-19: Current Status

Overview
Journal Viruses
Publisher MDPI
Specialty Microbiology
Date 2023 Nov 25
PMID 38005826
Authors
Affiliations
Soon will be listed here.
Abstract

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic. The interplay between innate and adaptive immune responses plays a crucial role in managing COVID-19. Cell therapy has recently emerged as a promising strategy to modulate the immune system, offering immense potential for the treatment of COVID-19 due to its customizability and regenerative capabilities. This review provides an overview of the various subsets of immune cell subsets implicated in the pathogenesis of COVID-19 and a comprehensive summary of the current status of immune cell therapy in COVID-19 treatment.

Citing Articles

Comprehensive Review of COVID-19: Epidemiology, Pathogenesis, Advancement in Diagnostic and Detection Techniques, and Post-Pandemic Treatment Strategies.

Chung Y, Lam C, Tan P, Tsang H, Wong S Int J Mol Sci. 2024; 25(15).

PMID: 39125722 PMC: 11312261. DOI: 10.3390/ijms25158155.

References
1.
Zhou R, To K, Wong Y, Liu L, Zhou B, Li X . Acute SARS-CoV-2 Infection Impairs Dendritic Cell and T Cell Responses. Immunity. 2020; 53(4):864-877.e5. PMC: 7402670. DOI: 10.1016/j.immuni.2020.07.026. View

2.
Labanieh L, Mackall C . CAR immune cells: design principles, resistance and the next generation. Nature. 2023; 614(7949):635-648. DOI: 10.1038/s41586-023-05707-3. View

3.
Xu X, Jiang W, Chen L, Xu Z, Zhang Q, Zhu M . Evaluation of the safety and efficacy of using human menstrual blood-derived mesenchymal stromal cells in treating severe and critically ill COVID-19 patients: An exploratory clinical trial. Clin Transl Med. 2021; 11(2):e297. PMC: 7839959. DOI: 10.1002/ctm2.297. View

4.
Keller M, Harris K, Jensen-Wachspress M, Kankate V, Lang H, Lazarski C . SARS-CoV-2-specific T cells are rapidly expanded for therapeutic use and target conserved regions of the membrane protein. Blood. 2020; 136(25):2905-2917. PMC: 7746091. DOI: 10.1182/blood.2020008488. View

5.
Cottle C, Porter A, Lipat A, Turner-Lyles C, Nguyen J, Moll G . Impact of Cryopreservation and Freeze-Thawing on Therapeutic Properties of Mesenchymal Stromal/Stem Cells and Other Common Cellular Therapeutics. Curr Stem Cell Rep. 2022; 8(2):72-92. PMC: 9045030. DOI: 10.1007/s40778-022-00212-1. View