Indonesian Euphorbiaceae: Ethnobotanical Survey, In Vitro Antibacterial, Antitumour Screening and Phytochemical Analysis of

Overview

Journal Plants (Basel)

Date 2023 Nov 25

PMID 38005733

Authors

Dyke Gita Wirasisya

Annamaria Kincses

Livia Vidacs

Nikoletta Szemeredi

Gabriella Spengler

Anita Barta

I Gde Mertha

Judit Hohmann

Affiliations

Soon will be listed here.

Abstract

Indonesia is among the countries with the most significant biodiversity globally. , the traditional medicine of Indonesia, predominantly uses herbal materials and is an integral component of the Indonesian healthcare system. The present study reviewed the ethnobotanical data of seven Indonesian Euphorbiaceae species, namely , , , , , , and , based on the RISTOJA database and other literature sources. An antimicrobial screening of the plant extracts was performed in 15 microorganisms using the disk diffusion and broth microdilution methods, and the antiproliferative effects were examined in drug-sensitive Colo 205 and resistant Colo 320 cells by the MTT assay. The antimicrobial testing showed a high potency of , , , , and extracts (MIC = 12.5-500 µg/mL) against different bacteria. In the antitumour screening, remarkable activities (IC 0.23-2.60 µg/mL) were demonstrated for the extracts of , , , and against Colo 205 cells. The -hexane extract of , with an IC value of 0.24 ± 0.06 µg/mL (Colo 205), was subjected to multistep chromatographic separation, and 24-methylene-cycloartan-3-ol, jolkinolide E, tetra--butyl-diphenyl ether, -tocopherol, and -sitosterol were isolated.

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