Bioactivity of the Genus : A Review of the Last 10 Years

Overview

Journal Pharmaceuticals (Basel)

Publisher MDPI

Specialty Chemistry

Date 2023 Nov 25

PMID 38004438

Authors

Aida Parra-Naranjo

Cecilia Delgado-Montemayor

Ricardo Salazar-Aranda

Noemi Waksman-Minsky

Affiliations

Soon will be listed here.

Abstract

is a genus of plants whose biological activity has been widely studied. The importance of this genus, particularly , as a source of treatment for various conditions is evidenced by the large number of new studies that have evaluated its biological activity. Accordingly, the objective of this review was to compile the information published in the last ten years concerning the biological activities reported for spp. The present work includes 92 publications that evaluate 29 bioactivities and toxicological and genotoxic information on five species of this genus. Among the pharmacological effects reported, the antioxidant, hepatoprotective, neuroprotective, hypoglycemic, and aphrodisiac activities seem more promising. Phytochemicals and standardized plant extracts could offer alternative therapeutic remedies for various diseases. Although several flavonoids, cyanogenic glycosides, monoterpenoids, triterpenoids, and fatty acids have been isolated for plants, future research should focus on the identification of the main active principles responsible for these pharmacological activities, as well as to perform clinical trials to support the laboratory results.

References

de Lima Reboucas E, Wlisses da Silva A, Rodrigues M, Kueirislene Amancio Ferreira M, Mendes F, Marinho M . Antinociceptive, anti-inflammatory and hypoglycemic activities of the ethanolic Sm. flower extract in adult zebrafish (). J Biomol Struct Dyn. 2021; 40(23):13062-13074. DOI: 10.1080/07391102.2021.1981449. View

Yam M, Loh Y, Tan C, Adam S, Abdul Manan N, Basir R . General Pathways of Pain Sensation and the Major Neurotransmitters Involved in Pain Regulation. Int J Mol Sci. 2018; 19(8). PMC: 6121522. DOI: 10.3390/ijms19082164. View

Souza N, de Oliveira J, Morrone M, DOliveira Albanus R, Amarante M, da Silva Camillo C . Turnera subulata Anti-Inflammatory Properties in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages. J Med Food. 2016; 19(10):922-930. DOI: 10.1089/jmf.2016.0047. View

Olejarz W, Kubiak-Tomaszewska G, Chrzanowska A, Lorenc T . Exosomes in Angiogenesis and Anti-angiogenic Therapy in Cancers. Int J Mol Sci. 2020; 21(16). PMC: 7461570. DOI: 10.3390/ijms21165840. View

Garcia M, Monzote L, Montalvo A, Scull R . Screening of medicinal plants against Leishmania amazonensis. Pharm Biol. 2010; 48(9):1053-8. DOI: 10.3109/13880200903485729. View

Adame-Miranda S, Granados-Guzman G, Silva-Mares D, Acevedo-Fernandez J, Waksman-Minsky N, Salazar-Aranda R . Evaluation of antihyperglycemic activity of plants in northeast mexico. Cell Mol Biol (Noisy-le-grand). 2021; 67(1):212-218. DOI: 10.14715/cmb/2021.67.1.30. View

Andrade-Pinheiro J, Sobral de Souza C, Ribeiro D, Alencar Silva A, da Silva V, Lucas Dos Santos A . LC-MS Analysis and Antifungal Activity of Sm. Plants (Basel). 2023; 12(2). PMC: 9862381. DOI: 10.3390/plants12020415. View

Bernardo J, Ferreres F, Gil-Izquierdo A, Valentao P, Andrade P . Medicinal species as MTDLs: Turnera diffusa Willd. Ex Schult inhibits CNS enzymes and delays glutamate excitotoxicity in SH-SY5Y cells via oxidative damage. Food Chem Toxicol. 2017; 106(Pt A):466-476. DOI: 10.1016/j.fct.2017.06.014. View

Reyes-Becerril M, Ginera P, Silva-Jara J, Macias A, Velazquez-Carriles C, Alcaraz-Melendez L . Assessment of chemical, biological and immunological properties of "Damiana de California" Turnera diffusa Willd extracts in Longfin yellowtail (Seriola rivoliana) leukocytes. Fish Shellfish Immunol. 2020; 100:418-426. DOI: 10.1016/j.fsi.2020.03.045. View

10.

Delgado-Montemayor C, Cordero-Perez P, Torres-Gonzalez L, Salazar-Cavazos M, Saucedo A, Paniagua-Vega D . Development of a Hepatoprotective Herbal Drug from . Evid Based Complement Alternat Med. 2022; 2022:5114948. PMC: 8763504. DOI: 10.1155/2022/5114948. View

11.

Salminen A, Kaarniranta K, Kauppinen A . Photoaging: UV radiation-induced inflammation and immunosuppression accelerate the aging process in the skin. Inflamm Res. 2022; 71(7-8):817-831. PMC: 9307547. DOI: 10.1007/s00011-022-01598-8. View

12.

Cragg G, Boyd M, Cardellina 2nd J, Newman D, SNADER K, McCloud T . Ethnobotany and drug discovery: the experience of the US National Cancer Institute. Ciba Found Symp. 1994; 185:178-90; discussion 190-6. DOI: 10.1002/9780470514634.ch13. View

13.

Chaurasiya N, Zhao J, Pandey P, Doerksen R, Muhammad I, Tekwani B . Selective Inhibition of Human Monoamine Oxidase B by Acacetin 7-Methyl Ether Isolated from (Damiana). Molecules. 2019; 24(4). PMC: 6412401. DOI: 10.3390/molecules24040810. View

14.

Hernandez Bautista R, Mahmoud A, Konigsberg M, Lopez Diaz Guerrero N . Obesity: Pathophysiology, monosodium glutamate-induced model and anti-obesity medicinal plants. Biomed Pharmacother. 2019; 111:503-516. DOI: 10.1016/j.biopha.2018.12.108. View

15.

Oliveira A, Costa Junior L, Lima A, Silva C, Ribeiro M, Mesquista J . Anthelmintic activity of plant extracts from Brazilian savanna. Vet Parasitol. 2017; 236:121-127. DOI: 10.1016/j.vetpar.2017.02.005. View

16.

Harun N, Septama A, Ahmad W, Suppian R . Immunomodulatory effects and structure-activity relationship of botanical pentacyclic triterpenes: A review. Chin Herb Med. 2022; 12(2):118-124. PMC: 9476727. DOI: 10.1016/j.chmed.2019.11.007. View

17.

Sandroni P . Aphrodisiacs past and present: a historical review. Clin Auton Res. 2002; 11(5):303-7. DOI: 10.1007/BF02332975. View

18.

de Souza Gracioso J, Vilegas W, Hiruma-Lima C, Souza Brito A . Effects of tea from Turnera ulmifolia L. on mouse gastric mucosa support the Turneraceae as a new source of antiulcerogenic drugs. Biol Pharm Bull. 2002; 25(4):487-91. DOI: 10.1248/bpb.25.487. View

19.

Forman H, Zhang H . Targeting oxidative stress in disease: promise and limitations of antioxidant therapy. Nat Rev Drug Discov. 2021; 20(9):689-709. PMC: 8243062. DOI: 10.1038/s41573-021-00233-1. View

20.

Matzkin M, Calandra R, Rossi S, Bartke A, Frungieri M . Hallmarks of Testicular Aging: The Challenge of Anti-Inflammatory and Antioxidant Therapies Using Natural and/or Pharmacological Compounds to Improve the Physiopathological Status of the Aged Male Gonad. Cells. 2021; 10(11). PMC: 8619877. DOI: 10.3390/cells10113114. View