Hemorrhagic Fever with Renal Syndrome Patients Exhibit Increased Levels of Lipocalin-2, Endothelin-1 and NT-proBNP

Overview

Journal Life (Basel)

Specialty Biology

Date 2023 Nov 25

PMID 38004329

Authors

Lidija Cvetko Krajinovic

Kristian Bodulic

Renata Laskaj

Branka Zibrat

Petra Svoboda Karic

Ivan-Christian Kurolt

Mihaela Kordun

Antea Topic

Rok Civljak

Tomislava Skuhala

Alemka Markotic

Affiliations

Soon will be listed here.

Abstract

Hemorrhagic fever with renal syndrome (HFRS) is an acute zoonotic disease caused by viruses of the genus. This syndrome is characterized by renal and cardiopulmonary implications detectable with different biomarkers. Here, we explored the role of serum and urine levels of lipocalin-2, endothelin-1 and N-terminal pro-brain natriuretic peptide (NT-proBNP) in HFRS pathology. A total of twenty-eight patients hospitalized due to a Puumala orthohantavirus infection were included, with serum and urine samples collected on patient admission (acute phase) and discharge (convalescent phase). In comparison to healthy individuals, patients exhibited significantly higher acute-phase serum and urine levels of lipocalin-2, serum levels of endothelin-1 and serum and urine levels of NT-proBNP. Patients in the convalescent phase showed a significant decrease in urine lipocalin-2, serum endothelin-1 and serum and urine NT-proBNP levels. We recorded a strong correlation between serum levels of lipocalin-2 and endothelin-1 and urine levels of lipocalin-2 with several kidney injury markers, such as serum creatinine, urea, urine white blood cell count and proteinuria. We also demonstrated an independent correlation of serum and urine lipocalin-2 levels with acute kidney injury in HFRS. All in all, our results show an involvement of NT-proBNP, lipocalin-2 and endothelin-1 in the renal and cardiac pathology of HFRS.

Citing Articles

A Comprehensive Analysis of Renal and Endothelium Dysfunction Markers Fourteen Years after Hemorrhagic Fever with Renal Syndrome Contraction.

Ledina D, Ivic I, Tadin A, Bodulic K, LeDuc J, Markotic A Life (Basel). 2024; 14(5).

PMID: 38792596 PMC: 11122023. DOI: 10.3390/life14050575.

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