Ethanol Extract of Radix Asteris Suppresses Osteoclast Differentiation and Alleviates Osteoporosis

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2023 Nov 25

PMID 38003715

Authors

Sung-Ju Lee

Hyun Yang

Seong Cheol Kim

Dong Ryun Gu

Jin Ah Ryuk

Seon-A Jang

Hyunil Ha

Affiliations

Soon will be listed here.

Abstract

Radix Asteris, the root of L. f., is historically significant in East Asian medicine for treating respiratory conditions. Yet, its implications on bone health remain uncharted. This research investigated the impact of an aqueous ethanol extract of Radix Asteris (EERA) on osteoclast differentiation and its prospective contribution to osteoporosis management. We discerned that EERA retards osteoclast differentiation by inhibiting receptor activator of nuclear factor kappa-B ligand (RANKL) expression and obstructing RANKL-induced osteoclastogenesis. EERA markedly suppressed RANKL-induced expression of NFATc1, a pivotal osteoclastogenic factor, via modulating early RANK signaling. EERA's therapeutic potential was underscored by its defense against trabecular bone degradation and its counteraction to increased body and perigonadal fat in ovariectomized mice, mirroring postmenopausal physiological changes. In the phytochemical analysis of EERA, we identified several constituents recognized for their roles in regulating bone and fat metabolism. Collectively, our findings emphasize the potential of EERA in osteoclast differentiation modulation and in the management of osteoporosis and associated metabolic changes following estrogen depletion, suggesting its suitability as an alternative therapeutic strategy for postmenopausal osteoporosis intertwined with metabolic imbalances.

Citing Articles

Research on Bone Cells in Health and Disease.

Gyori D Int J Mol Sci. 2024; 25(16).

PMID: 39201445 PMC: 11354530. DOI: 10.3390/ijms25168758.

An updated and comprehensive review of the morphology, ethnomedicinal uses, phytochemistry, and pharmacological activity of L. f.

Fan X, Qin Z, Wen J, Wang Z, Xiao W Heliyon. 2024; 10(15):e35267.

PMID: 39166058 PMC: 11334675. DOI: 10.1016/j.heliyon.2024.e35267.

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