Extracellular Vesicles and Their Role in Lung Infections

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2023 Nov 25

PMID 38003329

Authors

Shadi Hambo

Hani Harb

Affiliations

Soon will be listed here.

Abstract

Lung infections are one of the most common causes of death and morbidity worldwide. Both bacterial and viral lung infections cause a vast number of infections with varying severities. Extracellular vesicles (EVs) produced by different cells due to infection in the lung have the ability to modify the immune system, leading to either better immune response or worsening of the disease. It has been shown that both bacteria and viruses have the ability to produce their EVs and stimulate the immune system for that. In this review, we investigate topics from EV biogenesis and types of EVs to lung bacterial and viral infections caused by various bacterial species. , and infections are covered intensively in this review. Moreover, various viral lung infections, including SARS-CoV-2 infections, have been depicted extensively. In this review, we focus on eukaryotic-cell-derived EVs as an important component of disease pathogenesis. Finally, this review holds high novelty in its findings and literature review. It represents the first time to cover all different information on immune-cell-derived EVs in both bacterial and viral lung infections.

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References

Hugel B, Martinez M, Kunzelmann C, Freyssinet J . Membrane microparticles: two sides of the coin. Physiology (Bethesda). 2005; 20:22-7. DOI: 10.1152/physiol.00029.2004. View

Gambardella J, Kansakar U, Sardu C, Messina V, Jankauskas S, Marfella R . Exosomal miR-145 and miR-885 Regulate Thrombosis in COVID-19. J Pharmacol Exp Ther. 2022; 384(1):109-115. PMC: 9827505. DOI: 10.1124/jpet.122.001209. View

Koeppen K, Nymon A, Barnaby R, Bashor L, Li Z, Hampton T . Let-7b-5p in vesicles secreted by human airway cells reduces biofilm formation and increases antibiotic sensitivity of . Proc Natl Acad Sci U S A. 2021; 118(28). PMC: 8285967. DOI: 10.1073/pnas.2105370118. View

Cheng Y, Schorey J . Extracellular vesicles deliver RNA to promote host immunity and bacterial killing. EMBO Rep. 2019; 20(3). PMC: 6399609. DOI: 10.15252/embr.201846613. View

Berry F, Morin-Dewaele M, Majidipur A, Jamet T, Bartier S, Ignjatovic E . Proviral role of human respiratory epithelial cell-derived small extracellular vesicles in SARS-CoV-2 infection. J Extracell Vesicles. 2022; 11(10):e12269. PMC: 9587708. DOI: 10.1002/jev2.12269. View

Tricarico C, Clancy J, DSouza-Schorey C . Biology and biogenesis of shed microvesicles. Small GTPases. 2016; 8(4):220-232. PMC: 5680703. DOI: 10.1080/21541248.2016.1215283. View

Todkar K, Chikhi L, Desjardins V, El-Mortada F, Pepin G, Germain M . Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs. Nat Commun. 2021; 12(1):1971. PMC: 8009912. DOI: 10.1038/s41467-021-21984-w. View

Allen E, Lempke S, Miller M, Bush D, Braswell B, Estes C . Effect of extracellular vesicles from S. aureus-challenged human neutrophils on macrophages. J Leukoc Biol. 2020; 108(6):1841-1850. PMC: 7686018. DOI: 10.1002/JLB.3AB0320-156R. View

Maemura T, Fukuyama S, Kawaoka Y . High Levels of miR-483-3p Are Present in Serum Exosomes Upon Infection of Mice With Highly Pathogenic Avian Influenza Virus. Front Microbiol. 2020; 11:144. PMC: 7026002. DOI: 10.3389/fmicb.2020.00144. View

10.

Ching K, de Vries M, Gago J, Dancel-Manning K, Sall J, Rice W . ACE2-containing defensosomes serve as decoys to inhibit SARS-CoV-2 infection. PLoS Biol. 2022; 20(9):e3001754. PMC: 9469972. DOI: 10.1371/journal.pbio.3001754. View

11.

Barnwal A, Basu B, Tripathi A, Soni N, Mishra D, Banerjee A . SARS-CoV-2 Spike Protein-Activated Dendritic Cell-Derived Extracellular Vesicles Induce Antiviral Immunity in Mice. ACS Biomater Sci Eng. 2022; 8(12):5338-5348. DOI: 10.1021/acsbiomaterials.2c01094. View

12.

Vagner T, Spinelli C, Minciacchi V, Balaj L, Zandian M, Conley A . Large extracellular vesicles carry most of the tumour DNA circulating in prostate cancer patient plasma. J Extracell Vesicles. 2018; 7(1):1505403. PMC: 6084494. DOI: 10.1080/20013078.2018.1505403. View

13.

Torralba D, Baixauli F, Villarroya-Beltri C, Fernandez-Delgado I, Latorre-Pellicer A, Acin-Perez R . Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts. Nat Commun. 2018; 9(1):2658. PMC: 6037695. DOI: 10.1038/s41467-018-05077-9. View

14.

Ludlow M . Respiratory syncytial virus infection in the modern era. Curr Opin Infect Dis. 2023; 36(3):155-163. DOI: 10.1097/QCO.0000000000000917. View

15.

Girard T, Antunes L, Zhang N, Amrute J, Subramanian R, Eldem I . Peripheral blood mononuclear cell tissue factor (F3 gene) transcript levels and circulating extracellular vesicles are elevated in severe coronavirus 2019 (COVID-19) disease. J Thromb Haemost. 2023; 21(3):629-638. PMC: 9773443. DOI: 10.1016/j.jtha.2022.11.033. View

16.

Zebardast A, Latifi T, Shabani M, Hasanzadeh A, Danesh M, Babazadeh S . Thrombotic storm in coronavirus disease 2019: from underlying mechanisms to its management. J Med Microbiol. 2022; 71(11). DOI: 10.1099/jmm.0.001591. View

17.

Qu X, Li Q, Yang J, Zhao H, Wang F, Zhang F . Double-Stranded DNA in Exosomes of Malignant Pleural Effusions as a Novel DNA Source for EGFR Mutation Detection in Lung Adenocarcinoma. Front Oncol. 2019; 9:931. PMC: 6773809. DOI: 10.3389/fonc.2019.00931. View

18.

Herrmann I, Bertazzo S, OCallaghan D, Schlegel A, Kallepitis C, Antcliffe D . Differentiating sepsis from non-infectious systemic inflammation based on microvesicle-bacteria aggregation. Nanoscale. 2015; 7(32):13511-20. DOI: 10.1039/c5nr01851j. View

19.

Lam S, Huang X, Shui G . Neurological aspects of SARS-CoV-2 infection: lipoproteins and exosomes as Trojan horses. Trends Endocrinol Metab. 2022; 33(8):554-568. PMC: 9058057. DOI: 10.1016/j.tem.2022.04.011. View

20.

Xia B, Pan X, Luo R, Shen X, Li S, Wang Y . Extracellular vesicles mediate antibody-resistant transmission of SARS-CoV-2. Cell Discov. 2023; 9(1):2. PMC: 9821354. DOI: 10.1038/s41421-022-00510-2. View