Investigation of the Relationship Between Apolipoprotein E Alleles and Serum Lipids in Alzheimer's Disease: A Meta-Analysis

Overview

Journal Brain Sci

Publisher MDPI

Date 2023 Nov 25

PMID 38002514

Authors

Huaxue Xu

Jiajia Fu

Risna Begam Mohammed Nazar

Jing Yang

Sihui Chen

Yan Huang

Ting Bao

Xueping Chen

Affiliations

Soon will be listed here.

Abstract

Prior studies have yielded mixed findings concerning the association between apolipoprotein E()- and serum lipids in patients with Alzheimer's disease (AD) and healthy individuals. Some studies suggested a relationship between and serum lipids in patients with AD and healthy individuals, whereas others proposed that the allele affects lipids only in patients with AD. Our study aimed to investigate whether alleles have a distinct impact on lipids in AD. We conducted a comprehensive search of the PubMed and Embase databases for all related studies that investigate and serum lipids of AD from the inception to 30 May 2022. Elevated total cholesterol (TC) and low-density lipoprotein (LDL) levels were found in allele carriers compared with non-carriers. No significant differences were found for high-density lipoprotein (HDL) and triglyceride (TG) levels in allele carriers compared to non-carriers. Notably, elevated TC and LDL levels showed considerable heterogeneity between patients with AD and healthy controls. A network meta-analysis did not find a distinct effect of carrying one or two alleles on lipid profiles. Higher TC and LDL levels were found in allele carriers compared with non-carriers, and the difference was more significant in patients with AD than in healthy controls.

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