Ageing and Inflammation: What Happens in Periodontium?

Overview

Journal Bioengineering (Basel)

Date 2023 Nov 25

PMID 38002398

Authors

Luying Zhu

Zhongyuan Tang

Renjie Hu

Min Gu

Yanqi Yang

Affiliations

Soon will be listed here.

Abstract

Periodontitis is a chronic inflammatory disease with a high incidence and severity in the elderly population, making it a significant public health concern. Ageing is a primary risk factor for the development of periodontitis, exacerbating alveolar bone loss and leading to tooth loss in the geriatric population. Despite extensive research, the precise molecular mechanisms underlying the relationship between ageing and periodontitis remain elusive. Understanding the intricate mechanisms that connect ageing and inflammation may help reveal new therapeutic targets and provide valuable options to tackle the challenges encountered by the rapidly expanding global ageing population. In this review, we highlight the latest scientific breakthroughs in the pathways by which inflammaging mediates the decline in periodontal function and triggers the onset of periodontitis. We also provide a comprehensive overview of the latest findings and discuss potential avenues for future research in this critical area of investigation.

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References

Campisi J . Aging, cellular senescence, and cancer. Annu Rev Physiol. 2012; 75:685-705. PMC: 4166529. DOI: 10.1146/annurev-physiol-030212-183653. View

Slots J . Periodontitis: facts, fallacies and the future. Periodontol 2000. 2017; 75(1):7-23. DOI: 10.1111/prd.12221. View

Graves D, Alshabab A, Albiero M, Mattos M, Correa J, Chen S . Osteocytes play an important role in experimental periodontitis in healthy and diabetic mice through expression of RANKL. J Clin Periodontol. 2017; 45(3):285-292. PMC: 5811370. DOI: 10.1111/jcpe.12851. View

Franceschi C, Campisi J . Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J Gerontol A Biol Sci Med Sci. 2014; 69 Suppl 1:S4-9. DOI: 10.1093/gerona/glu057. View

Guo Y, Nguyen K, Potempa J . Dichotomy of gingipains action as virulence factors: from cleaving substrates with the precision of a surgeon's knife to a meat chopper-like brutal degradation of proteins. Periodontol 2000. 2010; 54(1):15-44. PMC: 2924770. DOI: 10.1111/j.1600-0757.2010.00377.x. View

Thorbert-Mros S, Larsson L, Berglundh T . Cellular composition of long-standing gingivitis and periodontitis lesions. J Periodontal Res. 2014; 50(4):535-43. DOI: 10.1111/jre.12236. View

Li Q, Ma Y, Zhu Y, Zhang T, Zhou Y . Declined Expression of Histone Deacetylase 6 Contributes to Periodontal Ligament Stem Cell Aging. J Periodontol. 2016; 88(1):e12-e23. DOI: 10.1902/jop.2016.160338. View

Chen M, Zhong Y, Dong Q, Wong H, Wen Y . Global, regional, and national burden of severe periodontitis, 1990-2019: An analysis of the Global Burden of Disease Study 2019. J Clin Periodontol. 2021; 48(9):1165-1188. DOI: 10.1111/jcpe.13506. View

Yucel-Lindberg T, Bage T . Inflammatory mediators in the pathogenesis of periodontitis. Expert Rev Mol Med. 2013; 15:e7. DOI: 10.1017/erm.2013.8. View

10.

Huang X, Xie M, Xie Y, Mei F, Lu X, Li X . The roles of osteocytes in alveolar bone destruction in periodontitis. J Transl Med. 2020; 18(1):479. PMC: 7733264. DOI: 10.1186/s12967-020-02664-7. View

11.

Sako H, Omori K, Nakayama M, Mandai H, Ideguchi H, Yoshimura-Nakagawa S . The Fungal Metabolite (+)-Terrein Abrogates Inflammatory Bone Resorption via the Suppression of TNF-α Production in a Ligature-Induced Periodontitis Mouse Model. J Fungi (Basel). 2023; 9(3). PMC: 10055831. DOI: 10.3390/jof9030314. View

12.

Bruunsgaard H, Skinhoj P, Pedersen A, Schroll M, Pedersen B . Ageing, tumour necrosis factor-alpha (TNF-alpha) and atherosclerosis. Clin Exp Immunol. 2000; 121(2):255-60. PMC: 1905691. DOI: 10.1046/j.1365-2249.2000.01281.x. View

13.

Lio D, Scola L, Crivello A, Colonna-Romano G, Candore G, Bonafe M . Inflammation, genetics, and longevity: further studies on the protective effects in men of IL-10 -1082 promoter SNP and its interaction with TNF-alpha -308 promoter SNP. J Med Genet. 2003; 40(4):296-9. PMC: 1735442. DOI: 10.1136/jmg.40.4.296. View

14.

dAdda di Fagagna F . Living on a break: cellular senescence as a DNA-damage response. Nat Rev Cancer. 2008; 8(7):512-22. DOI: 10.1038/nrc2440. View

15.

Sansoni P, Vescovini R, Fagnoni F, Biasini C, Zanni F, Zanlari L . The immune system in extreme longevity. Exp Gerontol. 2007; 43(2):61-5. DOI: 10.1016/j.exger.2007.06.008. View

16.

Usui M, Okamatsu Y, Sato T, Hanatani T, Moritani Y, Sano K . Thymus-expressed chemokine enhances Porphyromonas gingivalis LPS-induced osteoclast formation via NFATc1 activation. Arch Oral Biol. 2016; 66:77-85. DOI: 10.1016/j.archoralbio.2016.02.011. View

17.

de Diego I, Veillard F, Sztukowska M, Guevara T, Potempa B, Pomowski A . Structure and mechanism of cysteine peptidase gingipain K (Kgp), a major virulence factor of Porphyromonas gingivalis in periodontitis. J Biol Chem. 2014; 289(46):32291-32302. PMC: 4231702. DOI: 10.1074/jbc.M114.602052. View

18.

Preshaw P, Taylor J . How has research into cytokine interactions and their role in driving immune responses impacted our understanding of periodontitis?. J Clin Periodontol. 2011; 38 Suppl 11:60-84. DOI: 10.1111/j.1600-051X.2010.01671.x. View

19.

Ross O, Curran M, Meenagh A, Williams F, Barnett Y, Middleton D . Study of age-association with cytokine gene polymorphisms in an aged Irish population. Mech Ageing Dev. 2003; 124(2):199-206. DOI: 10.1016/s0047-6374(02)00132-x. View

20.

Kukita A, Ichigi Y, Takigawa I, Watanabe T, Kukita T, Miyamoto H . Infection of RANKL-primed RAW-D macrophages with Porphyromonas gingivalis promotes osteoclastogenesis in a TNF-α-independent manner. PLoS One. 2012; 7(6):e38500. PMC: 3377672. DOI: 10.1371/journal.pone.0038500. View