» Articles » PMID: 38002398

Ageing and Inflammation: What Happens in Periodontium?

Overview
Date 2023 Nov 25
PMID 38002398
Authors
Affiliations
Soon will be listed here.
Abstract

Periodontitis is a chronic inflammatory disease with a high incidence and severity in the elderly population, making it a significant public health concern. Ageing is a primary risk factor for the development of periodontitis, exacerbating alveolar bone loss and leading to tooth loss in the geriatric population. Despite extensive research, the precise molecular mechanisms underlying the relationship between ageing and periodontitis remain elusive. Understanding the intricate mechanisms that connect ageing and inflammation may help reveal new therapeutic targets and provide valuable options to tackle the challenges encountered by the rapidly expanding global ageing population. In this review, we highlight the latest scientific breakthroughs in the pathways by which inflammaging mediates the decline in periodontal function and triggers the onset of periodontitis. We also provide a comprehensive overview of the latest findings and discuss potential avenues for future research in this critical area of investigation.

Citing Articles

Systematic review and meta-analysis on the prevalence and risk factors of oral frailty among older adults.

Huang P, Wu L, Zhang R, Chen S, Zhang Y, Chen Y Front Med (Lausanne). 2025; 12:1512927.

PMID: 39911869 PMC: 11794213. DOI: 10.3389/fmed.2025.1512927.


The effect of the Wnt pathway on the osteogenic differentiation of periodontal ligament stem cells in different environments.

Su Q, Huang F, Fang X, Lin Q PeerJ. 2025; 13:e18770.

PMID: 39763707 PMC: 11702355. DOI: 10.7717/peerj.18770.


Drug delivery for age-related bone diseases: From therapeutic targets to common and emerging therapeutic strategies.

Bi J, Zeng J, Liu X, Mo C, Yao M, Zhang J Saudi Pharm J. 2024; 32(12):102209.

PMID: 39697472 PMC: 11653637. DOI: 10.1016/j.jsps.2024.102209.


Anti-Osteoclastogenesis Potential of Cocoa Pod Husk (Theobroma cacao L.) Extract: In Silico and In Vivo Study.

Rahayu Y, Setiawatie E, Rahayu R, Siswandono S, Indrawati R, Setia Budi H Braz Dent J. 2024; 35:e246015.

PMID: 39630805 PMC: 11653760. DOI: 10.1590/0103-6440202406015.


Associations between immune-inflammatory markers, age, and periodontal status: a cross-sectional study.

Ucan Yarkac F, Babayigit O, Gokturk O Odontology. 2024; 112(4):1296-1306.

PMID: 38443702 DOI: 10.1007/s10266-024-00907-3.

References
1.
Campisi J . Aging, cellular senescence, and cancer. Annu Rev Physiol. 2012; 75:685-705. PMC: 4166529. DOI: 10.1146/annurev-physiol-030212-183653. View

2.
Slots J . Periodontitis: facts, fallacies and the future. Periodontol 2000. 2017; 75(1):7-23. DOI: 10.1111/prd.12221. View

3.
Graves D, Alshabab A, Albiero M, Mattos M, Correa J, Chen S . Osteocytes play an important role in experimental periodontitis in healthy and diabetic mice through expression of RANKL. J Clin Periodontol. 2017; 45(3):285-292. PMC: 5811370. DOI: 10.1111/jcpe.12851. View

4.
Franceschi C, Campisi J . Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J Gerontol A Biol Sci Med Sci. 2014; 69 Suppl 1:S4-9. DOI: 10.1093/gerona/glu057. View

5.
Guo Y, Nguyen K, Potempa J . Dichotomy of gingipains action as virulence factors: from cleaving substrates with the precision of a surgeon's knife to a meat chopper-like brutal degradation of proteins. Periodontol 2000. 2010; 54(1):15-44. PMC: 2924770. DOI: 10.1111/j.1600-0757.2010.00377.x. View