The Polyketides with Antimicrobial Activities from a Mangrove Endophytic Fungus ML-P8-2

Overview

Journal Mar Drugs

Publisher MDPI

Specialties Biology
Pharmacology

Date 2023 Nov 24

PMID 37999390

Authors

Yihao Yin

Qi Tan

Jianying Wu

Tao Chen

Wencong Yang

Zhigang She

Bo Wang

Affiliations

Soon will be listed here.

Abstract

Five new polyketides, including two chromones (-), two phenyl derivatives (-), and a tandyukusin derivative (), along with five known polyketides ( and -) were isolated from mangrove endophytic fungus ML-P8-2. The planar structures of compounds were elucidated via detailed 1D, 2D NMR, and HR-ESI-MS analysis. ECD spectra, optical rotation values calculation, and alkali hydrolysis were applied in the determination of the absolute configuration of the new compounds. In bioassays, and exhibited promising antifungal activities against , with an MIC value of 6.25 μM for both compounds. Moreover, displayed moderate AChE inhibitory activity with an IC value of 20.6 ± 0.3 μM.

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