Surveillance of Antimicrobial Resistance and Multidrug Resistance Prevalence of Clinical Isolates in a Regional Hospital in Northern Greece

Overview

Journal Antibiotics (Basel)

Specialty Pharmacology

Date 2023 Nov 24

PMID 37998797

Authors

Maria Tsalidou

Theodouli Stergiopoulou

Ioannis Bostanitis

Christina Nikaki

Kalypso Skoumpa

Theofani Koutsoukou

Paraskevi Papaioannidou

Affiliations

Soon will be listed here.

Abstract

Antimicrobial resistance is a global health threat resulting in increased morbidity and mortality. This retrospective study aimed to estimate antimicrobial susceptibility and multidrug resistance prevalence of clinical isolates in a regional hospital in Northern Greece during the last 6 years by analyzing the annual reports of the Laboratory of Microbiology. A total of 12,274 strains of certain bacteria were isolated from both hospitalized and ambulatory patients from biological products, mainly urine (range 63-78% during the study period). was the most frequent pathogen found (37.4%). A significant increase in the number of the main pathogens causing hospital-acquired infections (, , , ) was found in the time period of 2021-2023 compared to 2018-2020 ( < 0.0001). In total, 1767 multidrug-resistant bacterial strains were isolated, most of them belonging to (36.4%) and (39.6%), and were located in the intensive care unit (ICU) (59.8%). Extensively drug resistance (XDR) and pan drug resistance (PDR) were significantly higher in 2021-2023 than in 2018-2020 (XDR: 641/1087 in 2021-2023 vs. 374/680 in 2018-2020 and PDR: 134/1087 in 2021-2023 vs. 25/680 in 2018-2020, < 0.0001), resulting in an urgent need to establish certain strategies in order to eliminate this threatening condition.

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