Head and Neck Squamous Cell Carcinoma of Unknown Primary: A Diagnostic Work-Up

Overview

Journal Oncologist

Publisher Oxford University Press

Specialty Oncology

Date 2023 Nov 23

PMID 37995312

Authors

Meenakkshy Manoharan

Noah S Kalman

Guilherme Rabinowits

Affiliations

Soon will be listed here.

Abstract

The current work-up of the primary tumor site of a head and neck squamous cell carcinoma of unknown primary is not standardized and results in several time-consuming procedures that delay treatment initiation. This article seeks to consolidate contemporary strategies used to identify the primary tumor site of an unknown primary head and neck squamous cell carcinoma and offer recommendations based on current literature review.

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References

Chang S, Keeney M, Law M, Donovan J, Aubry M, Garcia J . Detection of human papillomavirus in non-small cell carcinoma of the lung. Hum Pathol. 2015; 46(11):1592-7. DOI: 10.1016/j.humpath.2015.07.012. View

Knoepp S, Roh M . Ancillary techniques on direct-smear aspirate slides: a significant evolution for cytopathology techniques. Cancer Cytopathol. 2012; 121(3):120-8. DOI: 10.1002/cncy.21214. View

Nagel T, Hinni M, Hayden R, Lott D . Transoral laser microsurgery for the unknown primary: role for lingual tonsillectomy. Head Neck. 2013; 36(7):942-6. DOI: 10.1002/hed.23372. View

Issing W, Taleban B, Tauber S . Diagnosis and management of carcinoma of unknown primary in the head and neck. Eur Arch Otorhinolaryngol. 2003; 260(8):436-43. DOI: 10.1007/s00405-003-0585-z. View

Mehanna H . The role of transoral surgery in the diagnosis of the carcinoma of unknown origin of the head and neck. Curr Opin Otolaryngol Head Neck Surg. 2023; 31(2):129-133. DOI: 10.1097/MOO.0000000000000880. View

Ebisumoto K, Sakai A, Maki D, Robinson K, Murakami T, Iijima H . Tumor detection with transoral use of flexible endoscopy for unknown primary head and neck cancer. Laryngoscope Investig Otolaryngol. 2021; 6(5):1037-1043. PMC: 8513428. DOI: 10.1002/lio2.656. View

Wu M, Burstein D, Yuan S, Nurse L, Szporn A, Zhang D . A comparative study of 200 fine needle aspiration biopsies performed by clinicians and cytopathologists. Laryngoscope. 2006; 116(7):1212-5. DOI: 10.1097/01.mlg.0000224507.07560.28. View

Kesse K, Manjaly G, Violaris N, Howlett D . Ultrasound-guided biopsy in the evaluation of focal lesions and diffuse swelling of the parotid gland. Br J Oral Maxillofac Surg. 2002; 40(5):384-8. View

Waltonen J, Ozer E, Schuller D, Agrawal A . Tonsillectomy vs. deep tonsil biopsies in detecting occult tonsil tumors. Laryngoscope. 2009; 119(1):102-6. DOI: 10.1002/lary.20017. View

10.

Rooper L, Windon M, Hernandez T, Miles B, Ha P, Ryan W . HPV-positive Squamous Cell Carcinoma of the Larynx, Oral Cavity, and Hypopharynx: Clinicopathologic Characterization With Recognition of a Novel Warty Variant. Am J Surg Pathol. 2020; 44(5):691-702. PMC: 7885126. DOI: 10.1097/PAS.0000000000001433. View

11.

Di Maio P, Iocca O, De Virgilio A, Giudice M, Pellini R, DAscanio L . Narrow band imaging in head and neck unknown primary carcinoma: A systematic review and meta-analysis. Laryngoscope. 2019; 130(7):1692-1700. DOI: 10.1002/lary.28350. View

12.

Kothari P, Randhawa P, Farrell R . Role of tonsillectomy in the search for a squamous cell carcinoma from an unknown primary in the head and neck. Br J Oral Maxillofac Surg. 2008; 46(4):283-7. DOI: 10.1016/j.bjoms.2007.11.017. View

13.

Karni R, Rich J, Sinha P, Haughey B . Transoral laser microsurgery: a new approach for unknown primaries of the head and neck. Laryngoscope. 2011; 121(6):1194-201. DOI: 10.1002/lary.21743. View

14.

Ferreira V, Sassi L, Zanicotti R, Albrecht Ramos G, Jung J, Schussel J . Core needle biopsy in the diagnosis of head and neck lesions: a retrospective study of 3 years. Eur Arch Otorhinolaryngol. 2016; 273(12):4469-4472. DOI: 10.1007/s00405-016-4139-6. View

15.

Nakao K, Yuge T, Mochiki M, Nibu K, Sugasawa M . Detection of Epstein-Barr virus in metastatic lymph nodes of patients with nasopharyngeal carcinoma and a primary unknown carcinoma. Arch Otolaryngol Head Neck Surg. 2003; 129(3):338-40. DOI: 10.1001/archotol.129.3.338. View

16.

Byrd J, Smith K, de Almeida J, Albergotti W, Davis K, Kim S . Transoral Robotic Surgery and the Unknown Primary: A Cost-Effectiveness Analysis. Otolaryngol Head Neck Surg. 2014; 150(6):976-82. PMC: 4167971. DOI: 10.1177/0194599814525746. View

17.

Waltonen J, Ozer E, Hall N, Schuller D, Agrawal A . Metastatic carcinoma of the neck of unknown primary origin: evolution and efficacy of the modern workup. Arch Otolaryngol Head Neck Surg. 2009; 135(10):1024-9. DOI: 10.1001/archoto.2009.145. View

18.

Mehta V, Johnson P, Tassler A, Kim S, Ferris R, Nance M . A new paradigm for the diagnosis and management of unknown primary tumors of the head and neck: a role for transoral robotic surgery. Laryngoscope. 2012; 123(1):146-51. DOI: 10.1002/lary.23562. View

19.

van Weert S, Rijken J, Plantone F, Bloemena E, Vergeer M, Lissenberg-Witte B . A systematic review on Transoral robotic surgery (TORS) for carcinoma of unknown primary origin: Has tongue base mucosectomy become indispensable?. Clin Otolaryngol. 2020; 45(5):732-738. PMC: 7496155. DOI: 10.1111/coa.13565. View

20.

Jakscha J, Zlobec I, Storck C, Obermann E, Tornillo L, Terracciano L . The clinical impact of p16 status in fine-needle aspirates of cervical lymph node metastasis of head and neck squamous cell carcinomas. Eur Arch Otorhinolaryngol. 2012; 270(2):661-7. DOI: 10.1007/s00405-012-2039-y. View